aaanalysis.dPULearnPlot.eval

static dPULearnPlot.eval(df_eval=None, figsize=(6, 4), dict_xlims=None, legend=True, legend_y=-0.175, colors=None)

Plot evaluation output of dPULearn comparing multiple sets of identified negatives.

Evaluation measures can be grouped into ‘Homogeneity’ measures (‘avg STD’ and ‘avg IQR’) assessing the similarity within the sets of identified negatives, and ‘Dissimilarity’ measures (‘avg AUC’, ‘avg KLD’) assessing the dissimilarity between the identified negatives and the other reference groups including positive samples (‘Pos’), unlabeled samples (‘Unl’), and ground-truth negative samples (‘Neg’) if given.

Parameters:

• df_eval (pd.DataFrame, shape (n_datasets, n_metrics)) –

  DataFrame with evaluation measures for sets of identified negatives. Each row corresponds to a specific dataset including identified negatives. required ‘columns’ are:

  • ’name’: Name of datasets containing identified negatives (typically named by identification approach).

  • ’avg_STD’: Average standard deviation (STD) assessing homogeneity of identified negatives.

  • ’avg_IQR’: Average interquartile range (IQR) assessing homogeneity of identified negatives.

  • ’avg_abs_AUC_DATASET’: Average absolute area under the curve (AUC), which assesses the similarity between the set of identified negatives and other datasets. ‘DATASET’ must be ‘pos’ (positive samples) and ‘unl’ (unlabeled samples), as well as, optionally, ‘neg’ (ground-truth negative samples).

  Optional columns include:

  • ’avg_KLD_DATASET’: The average Kullback-Leibler Divergence (KLD), which measures the distribution alignment between the set of identified negatives and other datasets (‘pos’, ‘unl’, or ‘neg’).

• figsize (tuple, default=(6, 4)) – Figure dimensions (width, height) in inches.

• dict_xlims (dict, optional) – A dictionary containing x-axis limits for subplots. Keys should be the subplot axis number ({0, 1, 2, 4}) and values should be tuple specifying (xmin, xmax). If None, x-axis limits are auto-scaled.

• legend (bool, default=True) – If True, legend is set under dissimilarity measures.

• legend_y (float, default=-0.175) – Legend position regarding the plot y-axis applied if legend=True.

• colors (list of str, optional) – List of colors for identified negatives and the following reference datasets: positive samples (‘Pos’), unlabeled samples (‘Unl’), and ground-truth negative samples (‘Neg’).

Returns:

• fig (plt.Figure) – Figure object for evaluation plot

• axes (array of plt.Axes) – Array of Axes objects, each representing a subplot within the figure. .

Notes

• Ground-truth negatives are only shown if provided by df_eval.

See also

• dPULearn.eval(): the respective computation method.

• comp_auc_adjusted() and comp_kld().

Examples

You can evaluate different sets of identified negative samples using the dPULearn().eval() method. Load first one of our example datasets with its respective features:

import matplotlib.pyplot as plt
import aaanalysis as aa
aa.options["verbose"] = False
# Dataset with positive (γ-secretase substrates)
# and unlabeled data (proteins with unknown substrate status)
df_seq = aa.load_dataset(name="DOM_GSEC_PU")
labels = df_seq["label"].to_numpy()
n_pos = sum([x == 1 for x in labels])
df_feat = aa.load_features(name="DOM_GSEC")
aa.display_df(df_seq)

	entry	sequence	label	tmd_start	tmd_stop	jmd_n	tmd	jmd_c
1	P05067	MLPGLALLLLAAWTA...GYENPTYKFFEQMQN	1	701	723	FAEDVGSNKG	AIIGLMVGGVVIATVIVITLVML	KKKQYTSIHH
2	P14925	MAGRARSGLLLLLLG...EEEYSAPLPKPAPSS	1	868	890	KLSTEPGSGV	SVVLITTLLVIPVLVLLAIVMFI	RWKKSRAFGD
3	P70180	MRSLLLFTFSACVLL...RELREDSIRSHFSVA	1	477	499	PCKSSGGLEE	SAVTGIVVGALLGAGLLMAFYFF	RKKYRITIER
4	Q03157	MGPTSPAARGQGRRW...HGYENPTYRFLEERP	1	585	607	APSGTGVSRE	ALSGLLIMGAGGGSLIVLSLLLL	RKKKPYGTIS
5	Q06481	MAATGTAAAAATGRL...GYENPTYKYLEQMQI	1	694	716	LREDFSLSSS	ALIGLLVIAVAIATVIVISLVML	RKRQYGTISH
6	P35613	MAAALFVLLGFALLG...HQNDKGKNVRQRNSS	1	323	345	IITLRVRSHL	AALWPFLGIVAEVLVLVTIIFIY	EKRRKPEDVL
7	P35070	MDRAARCSGASSLPL...DITPINEDIEETNIA	1	119	141	LFYLRGDRGQ	ILVICLIAVMVVFIILVIGVCTC	CHPLRKRRKR
8	P09803	MGARCRSFSALLLLL...RFKKLADMYGGGEDD	1	711	733	GIVAAGLQVP	AILGILGGILALLILILLLLLFL	RRRTVVKEPL
9	P19022	MCRIAGALRTLLPLL...PRFKKLADMYGGGDD	1	724	746	RIVGAGLGTG	AIIAILLCIIILLILVLMFVVWM	KRRDKERQAK
10	P16070	MDKFWWHAAWGLCLV...DETRNLQNVDMKIGV	1	650	672	GPIRTPQIPE	WLIILASLLALALILAVCIAVNS	RRRCGQKKKL
11	P09603	MTAPGAAGRCPPTTW...GSPLTQDDRQVELPV	1	496	518	EGSFSPQLQE	SVFHLLVPSVILVLLAVGGLLFY	RWRRRSHQEP
12	O94985	MLRRPAPALAPAARL...TRQQQLEWDDSTLSY	1	860	882	PHPFAVVPST	ATVVIVVCVSFLVFMIILGVFRI	RAAHRRTMRD
13	Q9H4D0	MLPGRLCWVPLLLAL...ARQAQLEWDDSTLPY	1	831	853	SSIQHSSVVP	SIATVVIIISVCMLVFVVAMGVY	RVRIAHQHFI
14	P78310	MALLLCFVLLCGVVD...IPVMIPAQSKDGSIV	1	236	258	RLNVVPPSNK	AGLIAGAIIGTLLALALIGLIIF	CCRKKRREEK
15	D3ZZK3	MAGIFYFILFSFLFG...MRTQMQQMHGRMVPV	1	548	570	RIIGDGANST	VLLVSVSGSVVLVVILIAAFVIS	RRRSKYSQAK
16	Q14118	MRMSVGLSLLLPLSG...KNMTPYRSPPPYVPP	1	753	775	KSSEDDVYLH	TVIPAVVVAAILLIAGIIAMICY	RKKRKGKLTL
17	Q63155	MENSLGCVWVPKLAF...EGLMKQLNAITGSAF	1	1099	1121	SVTPQKNSNL	LVITVVTVGVLTVLVVVIVAVIC	TRRSSAQQRK
18	Q61483	MGRRSALALAVVSAL...VLSAEKDECVIATEV	1	545	567	HMESQGGPFP	WVAVCAGVVLVLLLLLGCAAVVV	CVRLKLQKHQ
19	Q9ERC8	MWILALSLFQSFANV...HLKGNNPYAKSYTLV	1	1595	1617	EGLTTNEGLK	ILVTISCILVGVLLLFVLLLVVR	RRRREQRLKR
20	P54763	MAVRRLGAALLLLPL...QVMRAQMNQIQSVEV	1	543	565	YQTSIKEKLP	LIVGSSAAGLVFLIAVVVIAIVC	NRRGFERADS
21	Q15303	MKPATGLWVWVSLLV...TVLPPPPYRHRNTVV	1	653	675	TLPQHARTPL	IAAGVIGGLFILVIVGLTFAVYV	RRKSIKKKRA
22	P16882	MDLCQVFLTLALAVT...SCGYVSTDQLNKIMQ	1	274	296	ILEACEEDIQ	FPWFLIIIFGIFGVAVMLFVVIF	SKQQRIKMLI
23	P04439	MAVMAPRTLLLLLSG...DSAQGSDVSLTACKV	1	308	330	WELSSQPTIP	IVGIIAGLVLLGAVITGAVVAAV	MWRRKSSDRK
24	P08069	MKSGSGGGSPTSLWG...RKNERALPLPQSSTC	1	936	958	AKTGYENFIH	LIIALPVAVLLIVGGLVIMLYVF	HRKRNNSRLG
25	P27930	MLRLYVLVMGVSAFT...TVLWPHHQDFQSYPK	1	347	369	LRTTVKEASS	TFSWGIVLAPLSLAFLVLGGIWM	HRRCKHRTGK
26	Q9Y219	MRAQGRGRLPRRLLL...RAVRSINEARYAGKE	1	1083	1105	VVTGGSSTGL	LVPVLCGAFSVLWLACVVLCVWW	TRKRRKERER
27	P15382	MILSNTTAVTPFLTK...IEQPNTHLPETKPSP	1	44	66	SPRSSDGKLE	ALYVLMVLGFFGFFTLGIMLSYI	RSKKLEHSND
28	Q9Y6J6	MSTLSNFTQTLEDVF...TIHENIGAAGFKMSP	1	47	69	LQAKVDAENF	YYVILYLMVMIGMFSFIIVAILV	STVKSKRREH
29	P11627	MVVMLRYVWPLLLCS...SSGATSPINPAVALE	1	1124	1146	VSTTGSFASE	GWFIAFVSAIILLLLILLILCFI	KRSKGGKYSV
30	P01130	MGPWGWKLRWTVALL...SYPSRQMVSLEDDVA	1	787	809	GRGNEKKPSS	VRALSIVLPIVLLVFLCLGVFLL	WKNWRLKNIN
31	P16150	MATLLLLLGVLVVSP...APAPDEPEGGDGAAP	1	255	277	FRNPDENSRG	MLPVAVLVALLAVIVLVALLLLW	RRRQKRRTGA
32	P0CC10	MAQAHIQGSPCPLLP...LFKSGSKENVQETQI	1	573	595	LKDLDDVMKT	TKIIIGCFVAITFMAAVMLVAFY	KLRKQHQLHK
33	Q07954	MLTPPLLLLLPLLSA...LLGRGPEDEIGDPLA	1	4421	4443	HVFSQQQPGH	IASILIPLLLLLLLVLVAGVVFW	YKRRVQGAKG
34	O75581	MGAVLRSLLACSFCV...HHLYPPPPSPCTDSS	1	1371	1393	YPTEEPAPQA	TNTVGSVIGVIVTIFVSGTVYFI	CQRMLCPRMK
35	Q924X6	MGRPELGALRPLALL...KCKRVALSLEDDGLP	1	859	881	GSQMGSTVTA	AVIGVIVPIVVIALLCMSGYLIW	RNWKRKNTKS
36	Q12866	MGPAPLPLLLGLFLP...LLFADDSSEGSEVLM	1	502	524	STPAPGNADP	VLIIFGCFCGFILIGLILYISLA	IRKRVQETKF
37	P08581	MKAPAVLAPGILVLL...DDEVDTRPASFWETS	1	933	955	VIVQPDQNFT	GLIAGVVSISTALLLLLGFFLWL	KKRKQIKDLG
38	P15941	MTPGTQSPFFLLLLL...LSYTNPAVAATSANL	1	1159	1181	SAQSGAGVPG	WGIALLVLVCVLVALAIVYLIAL	AVCQCRRKNY
39	Q9JKF6	MARMGLAGAAGRWWG...SQNDGSFISKKEWYV	1	355	377	GRRAGQMPTA	IIGGVAGSVLLVLIVVGGIIVAL	RRRRHTFKGD
40	Q62765	MALPRCMWPNYVWRA...PHPHPHPHSHSTTRV	1	697	719	VDQRDYSTEL	SVTIAVGASLLFLNILAFAALYY	KKDKRRHDVH
41	O35516	MPALRPAALRALLWL...THMSEPPHSNMQVYA	1	1680	1702	SELESPRNAQ	LLYLLAVAVVIILFFILLGVIMA	KRKRKHGFLW
42	Q61982	MGLGARGRRRRRRLM...LGPQPEVTPKRQVMA	1	1644	1666	PLEAPEQSVP	LLPLLVAGAVFLLIIFILGVMVA	RRKREHSTLW
43	P31695	MQPQLLLLLLLPLNF...VHQEIPLNSVVRNLN	1	1441	1463	QAGTRPSANQ	LPWPILCSPVVGVLLLALGALLV	LQLIRRRRRE
44	Q8CJ26	MLYNVSKGVVYSDTA...VVQVLSSPAESSSVV	1	52	74	FPPEPPGASS	NIIPVYCALLATVILGLLAYVAF	KCWRSHKQRQ
45	Q63373	MYQRMLRCGAELGSP...SANKNKKNKDKEYYV	1	392	414	AEVIRESSST	TGMVVGIVAAAALCILILLYAMY	KYRNRDEGSY
46	P15209	MSPWLKWHGPAMARL...QNLAKASPVYLDILG	1	431	453	VADQSNREHL	SVYAVVVIASVVGFCLLVMLLLL	KLARHSKFGM
47	Q86YL7	MWKVSALLFVLGSAS...IIVVVMRKMSGRYSP	1	130	152	TVEKDGLSTV	TLVGIIVGVLLAIGFIGAIIVVV	MRKMSGRYSP
48	Q13308	MGAARGSPARPRRLP...EIASALGDSTVDSKP	1	704	726	GSPPPYKMIQ	TIGLSVGAAVAYIIAVLGLMFYC	KKRCKAKRLQ
49	P10586	MAPEPAPGRTMVPLV...RAALEYLGSFDHYAT	1	1262	1284	PAQQQEEPEM	LWVTGPVLAVILIILIVIAILLF	KRKRTHSPSS
50	P28828	MRTLGTCLVTLAGLL...YKFCYEVALEYLNSG	1	743	764	PEKQTDHTVK	IAGVIAGILLFVIIFLGVVLVM	KKRKLAKKRK
51	Q7M729	MSRAGNRGNTQARWL...GLPGSKAEEKPPTKV	1	161	183	VVDKLEKVDN	TVTLIILAVVGGVIGLLVCILLL	KKLITFILKK
52	O75056	MKPGPPHRAGAAHGA...SVTYQKPDKQEEFYA	1	387	409	KSILERKEVL	VAVIVGGVVGALFAAFLVTLLIY	RMKKKDEGSY
53	P78324	MEPAGPAPGRLGPLL...EPSFSEYASVQVPRK	1	372	394	AENTGSNERN	IYIVVGVVCTLLVALLMAALYLV	RIRQKKAQGS
54	Q92673	MATRSSRRESRLPFL...PMITGFSDDVPMVIA	1	2136	2158	SATQAARSTD	VAAVVVPILFLILLSLGVGFAIL	YTKHRRLQSS
55	Q99523	MERPWGAADGLSRWP...NKSGYHDDSDEDLLE	1	756	778	SPEKQNSKSN	SVPIILAIVGLMLVTVVAGVLIV	KKYVCGGRFL
56	Q8BGV3	MARGLDLAPLLLLLL...VELKELGEMRSEPSL	1	269	291	PPQFSMKRLT	AGVIAVIAVVSVAVVAGVVVLVV	TKRRKSGKYK
57	P35590	MVWRVPPFLLPILFL...ENFTYAGIDATAEEA	1	764	786	EEGLDQQLIL	AVVGSVSATCLTILAALLTLVCI	RRSCLHRRRT
58	P08138	MGAGATGRAMDGPRL...LVESLCSESTATSPV	1	250	272	QPVVTRGTTD	NLIPVYCSILAAVVVGLVAYIAF	KRWNSCKQNK
59	Q02223	MLQMAGQCSQNEYFD...AALSATEIEKSISAR	1	54	76	SVTNSVKGTN	AILWTCLGLSLIISLAVFVLMFL	LRKINSEPLK
60	P19438	MGLSTVPDLLLPLVL...LCGPAALPPAPSLLR	1	212	234	VKGTEDSGTT	VLLPLVIFFGLCLLSLLFIGLMY	RYQRWKSKLY
61	Q06418	MALRRSMGRPGLPPL...RLLLLQQGLLPHSSC	1	429	451	QQGPPHSRTS	WVPVVLGVLTALVTAAALALILL	RKRRKETRFG
62	P30530	MAWRCPRMGRVPLAW...ADRGSPAAPGQEDGA	1	450	472	EPSTPAFSWP	WWYVLLGAVVAAACVLILALFLV	HRRKKETRYG
63	Q6EMK4	MCSRVPLLLPLLLLL...PGPGLQSPLHAKPYI	1	577	599	TQAREGNLPL	LIAPALAAVLLAALAAVGAAYCV	RRGRAMAAAA
64	P12821	MGAASGRRGPGLLLP...SHGPQFGSEVELRHS	2	1257	1276	GLDLDAQQAR	VGQWLLLFLGIALLVATLGL	SQRLFSIRHR
65	P36896	MAESAGASSFFPLVV...KKTLSQLSVQEDVKI	2	127	149	EHPSMWGPVE	LVGIIAGPVFLLFLIIIIVFLVI	NYHQRVYHNR
66	Q8NER5	MTRALCSALRQALLL...KKTISQLCVKEDCKA	2	114	136	PNAPKLGPME	LAIIITVPVCLLSIAAMLTVWAC	QGRQCSYRKK
67	P37023	MTLGSPRKGLLMLLM...LQKISNSPEKPKVIQ	2	119	141	PSEQPGTDGQ	LALILGPVLALLALVALGVLGLW	HVRRRQEKQR
68	O43184	MAARPLPVSPARALL...YPHQVPRSTHTAYIK	2	707	729	DSGPIRQADN	QGLTIGILVTILCLLAAGFVVYL	KRKTLIRLLF
69	Q13444	MRLALLWALGLLGAG...SRPAPPPPTVSSLYL	2	695	717	TTQLKATSSL	TTGLLLSLLVLLVLVMLGASYWY	RARLHQRLCQ
70	Q9Z0F8	MRRRLLILTTLVPFV...KLQRQSRVDSKETEC	2	672	694	NTFGKFLADN	IVGSVLVFSLIFWIPFSILVHCV	DKKLDKQYES
71	Q9Y3Q7	MFLLLALLTELGRLQ...NRNSSVVSESDDVGH	2	685	707	FYTEKGYNTH	WNNWFILSFCIFLPFFIVFTTVI	FKRNEISKSC
72	Q9R157	MPLLFILAELAMLFA...KRNERKIVPQGEHKI	2	684	703	TKRLSKNEDS	WVILGFFIFLPFIVTFLVGI	MKRNERKIVP
73	O35674	MPGRAGVARFCLLAL...EYRSQRVGAIISSKI	2	704	726	VDSGPLPPKS	VGPVIAGVFSALFVLAVLVLLCH	CYRQSHKLGK
74	O43506	MAVGEPLVHIRVTLL...VLFKKRTKSKEDEEG	2	692	714	MEGLNVMGKL	RYLSLLCLLPLVAFLLFCLHVLF	KKRTKSKEDE
75	Q9UKJ8	MAVDGTLVYIRVTLL...RQCSGPKETKAHSSG	2	685	707	PASAKRGVFL	PLIVIPSLSVLTFLFTVGLLMYL	RQCSGPKETK
76	Q9JI76	MECFIMLGADARTLM...KIPSGPKETKASSPG	2	687	709	SGPTSQKRRV	IITVLSITVPVLSILICLLIAGL	YRIYCKIPSG
77	O75077	MKPPGSSSRQPPLAG...NVKKRRFDPTQQGPI	2	794	816	GPKGPSATNL	IIGSIAGAILVAAIVLGGTGWGF	KNVKKRRFDP
78	Q9R160	MVAMSEALVHARITL...PSYETVKPPDEWANP	2	698	720	SKKDAPEKPN	VIIWLLPIICVAVVLSVLFCLSG	ATKKSREAAA
79	Q9R159	MQTTQRASSFAAAED...ENKEDTNEVMNTETE	2	706	728	TEKKHKKSIG	LVILFWILFACFSVLFIVFLFFL	RSYVELPMSE
80	Q9UKQ2	MLQGLLPVSLLLSVA...KDNPVSTPKDSNPKA	2	664	686	PDCDDSSVVF	HFSIVVGVLFPMAVIFVVVAMVI	RHQSSREKQK
81	Q9UKF5	MKMLLLLHCLGVFLS...PQLMPSQSQPPVTPS	2	676	698	PPPKRKKKKK	FCYLCILLLIVLFILLCCLYRLC	KKSKPIKKQQ
82	Q9UKF2	MRSVQIFLSQCRLLL...ESKRPKAKSVKKQKK	2	686	708	GLLRGAIPSS	IWVVSIIMFRLILLILSVVFVFF	RQVIGNHLKP
83	Q8TC27	MFRLWLLLAGLCGLL...RSKSQDSTQTQSSSN	2	681	703	IMERASGKTE	NTWLLGFLIALPILIVTTAIVLA	RKQLKKWFAK
84	Q9BZ11	MGWRPRRARGTPLLL...DPQADQVQMPRSCLW	2	13	35	WRPRRARGTP	LLLLLLLLLLWPVPGAGVLQGHI	PGQPVTPHWV
85	Q99965	MWRVLFLLSGLGGLR...YSSDEQPESESEPKG	2	689	711	IYHSKPMRWP	FFLFIPFFIIFCVLIAIMVKVNF	QRKKWRTEDY
86	Q3TTE0	MFLLLLLFLHLKGLQ...GSNTNVTSSGGSTSH	2	695	712	HSNLKKNQLQ	LILYISLPLLVMISAVVI	KQSKLSRVCD
87	Q9H2U9	MLPGCIFLMILLIPQ...SKDSRGIADPNQSAK	2	668	690	VACEETLHVT	NITILVVVLVLVIVGIGVLILLV	RYRKCIKLKQ
88	Q13443	MGSGARFPSGTLRVR...PARPAPAPPLYSSLT	2	699	718	NEMNTALRDG	LLVFFFLIVPLIVCAIFIFI	KRDQLWRSYF
89	Q60813	MSVAAAGRGFASSLS...SESSSSSSWSDSDSQ	2	741	763	KMEDEEVNLK	VMVLVVPIFLVVLLCCLMLIAYL	WSEVQEVVSP
90	Q8R534	MERLKLGKIPEHWCI...AAAEKKDEDEEEGEE	2	705	727	STEELILNLK	LIVLAVILVLMILLIIICIISAY	TKSETASEAG
91	A2AJA7	MCLPSHLLSTWVLFM...PESITSNPQSPPDLA	2	1161	1183	EVAAPVSVPV	AVGGALLFFMFLVLMGLGGWHWL	QKQHCPGQRS
92	Q86WK6	MHPHRDPRGLWLLLP...PESVSSVFSDTPIVV	2	371	393	FTLHGHHDTL	NTAYTTLVGCILSVVLVLIYLYL	TPCRCWCRGV
93	Q8K592	MLGTLGLWTLLPAAA...SPDPVGDTVQVYVNE	2	146	168	EPQATPGGPV	WMALLLLGMFLVLLLSSIILALL	QRKACRVQGG
94	Q9BXJ7	MGVLGRVLLWLQLCA...SYFVNPLFAGAEAEA	2	361	383	AHVWGSSAAG	LAGGVAAAVLLALLVLLVAPPLL	RRAGRLRWRR
95	P58335	MVAERSPARSPGSWL...DEVCIWECIEKELTA	2	319	341	IVTATECSNG	IAAIIVILVLLLLLGIGLMWWFW	PLCCKVVIKD
96	P51693	MGPASPAARGLSRRP...HGYENPTYRFLEERP	2	581	603	APAGTGVSRE	AVSGLLIMGAGGGSLIVLSMLLL	RRKKPYGAIS
97	O75882	MVAAAAATEARLRRR...RNRKQQPPAQPGTCI	2	1279	1301	AFSQHSNFMD	LVQFFVTFFSCFLSLLLVAAVVW	KIKQSCWASR
98	P27037	MGAAAKLAFAVFLIS...TMVTNVDFPPKESSL	2	139	161	PVTPKPPYYN	ILLYSLVPLMLIAGIVICAFWVY	RHHKMAYPPV
99	P56817	MAQALPWLLLWMGAG...RQQHDDFADDISLLK	2	455	477	YNIPQTDEST	LMTIAYVMAAICALFMLPLCLMV	CQWRCLRCLR
100	Q13145	MDRHSSYIFIWLQLE...VHWGMYSGHGKLEFV	2	154	176	SSKELWFRAA	VIAVPIAGGLILVLLIMLALRML	RSENKRLQDQ
101	Q13873	MTSSLQRPWRVPWLP...TATTMVSKDIGMNCL	2	152	174	PHSFNRDETI	IIALASVSVLAVLIVALCFGYRM	LTGDRKQGLH
102	P36894	MPQLYIYIRLLGAYL...KKTLAKMVESQDVKI	2	153	175	IGPFFDGSIR	WLVLLISMAVCIIAMIIFSSCFC	YKHYCKSISS
103	O00238	MLLRSAGKLNVGTKK...KKTLAKMSESQDIKL	2	126	148	RDFVDGPIHH	RALLISVTVCSLLLVLIILFCYF	RYKRQETRPR
104	Q9BWV1	MLRGTMTAWRGMRPE...GPLVRVSFETPPLTI	2	856	878	MVARSSDLPY	LIVGVVLGSIVLIIVTFIPFCLW	RAWSKQKHTT
105	Q13410	MAVFPSSGLPRCLLT...LHSKLIPTQPSQGAP	2	245	267	IPASSLPRLT	PWIVAVAVILMVLGLLTIGSIFF	TWRLYNERPR
106	Q8WVV5	MEPAAALHFSLPASL...EEGLKLHRVGTHQSL	2	264	286	ALAVILTASP	WMVSMTVILAVFIIFMAVSICCI	KKLQREKKIL
107	Q96KV6	MEPAAALHFSRPASL...HRELVVPQLPARKKV	2	246	268	ESFMPSRSPC	VVILPVIMIILMIPIAICIYWIN	NLQKEKKDSH
108	P78410	MKMASSLAFLLLNFH...LTRGEESSSDTNKSA	2	248	270	ADPFFRSAQP	WIAALAGTLPILLLLLAGASYFL	WRQQKEITAL
109	Q7Z6A9	MKTLPAMLGTGKLFW...VKEAPTEYASICVRS	2	153	175	PSKDEMASRP	WLLYRLLPLGGLPLLITTCFCLF	CCLRRHQGKQ
110	Q7TST0	MMKGSPSVPPAGCLL...YFTRNSMGLSATAQP	2	249	271	PEPFFPKTCP	WKVALVCSVLILLVLLGGISLGI	WKEHQVKRRE
111	Q6UXE8	MAFVLILVLSFYELV...EEKGTPIFICPVSWG	2	237	259	FFQPSPWRLA	SILLGLLCGALCGVVMGMIIVFF	KSKGKIQAEL
112	Q8BJE2	MADFSVFLGFLKQIP...YEPLDPAWAVNEAVS	2	259	281	LPRMSPWKKA	FVGTLVVLPLSLIVLTMLALRYF	YKLRSFQEKQ
113	A8MVZ5	MAVTCDPEAFLSICF...RQREKNKASLEEERE	2	253	275	FSRSSQFTAW	KAALPLILVAMGLVIAGGICIFW	KRQREKNKAS
114	Q86VB7	MSKLRMVLLEDSGSA...KEAILSHTEKENGNL	2	1049	1071	KATTGRSSRQ	SSFIAVGILGVVLLAIFVALFFL	TKKRRQRQRL
115	Q9NR16	MMLPQNSWHIDFGRC...DTSLLGVLPASEATK	2	1360	1382	LKSLNASSGH	LALILSSIFGLLLLVLFILFLTW	CRVQKQKHLP
116	P55291	MDAAFLLVLGLLAQS...LSPGALLPRHRGRTA	2	604	626	ALLAGGTGLS	LGALVIVLASALLLLVLVLLVAL	RARFWKQSRG
117	P33146	MGSALLLALGLLAQS...WGPRFARLADMYGHQ	2	603	625	ALRGGGVGVS	LGALVIVLASTVVLLVLILLAAL	RTRFRGHSRG
118	O75309	MVPAWLWLLCVSVPQ...DPDQPADSVPLKATV	2	786	808	RMKGMPTKLS	AVGILVGTLVAIGIFLILIFTHW	TMSRKKDPDQ
119	Q9R100	MVSAQLHFLCLLTLY...KVENPQSPENKPLRS	2	784	806	PAGRQDGIPT	VGMAVGILLTTFLVIGIILAVVF	IRMRKDKVEN
120	Q9H159	MNCYLLLRFMLGIPL...KRLACMFGSAVQSNN	2	596	618	ELVLSMGFKT	EVIIAILICIMIIFGFIFLTLGL	KQRRKQILFP
121	Q9H251	MGRHVATSCHVAWLL...LRDVIMETPLEITEL	2	3068	3090	LPDDMSALQM	AIIVLAILLFLAAMLFVLMNWYY	RTVHKRKLKA
122	Q8IXH8	MAMRSGRHPSLLLLL...ATPFEEIYSESGVPS	2	614	636	VELADAEVGL	HVGALFPVCAAFVALAVALLFLL	RCYFVLEPKR
123	P59862	MDTRGCAWLLLLLSL...STPSEAMCFTSRVPS	2	592	614	ECEEPSDTWL	LWWALSPVGAALMVLSAALLCLL	RCSCTFGPKR
124	Q8NFZ8	MGRARRFQWPLLLLW...LNGSDGHKRKEEFFI	2	324	346	VVEAQTSVPY	AIVGGILALLVFLIICVLVGMVW	CSVRQKGSYL
125	O43570	MPRRSLHAAAVLLLV...VIYKPATKMETEAHA	2	305	327	CTAAGLSLGI	ILSLALAGILGICIVVVVSIWLF	RRKSIKKGDN
126	Q9ULX7	MLFSALLLEVIWILA...RKSVVFTSAQATTEA	2	290	312	QAGSSYTTGE	MLSLGVGILVGCLCLLLAVYFIA	RKIRKKRLEN
127	Q16790	MAPLCPSPWLPLLIP...GGVSYRPAEVAETGA	2	411	433	AEPVQLNSCL	AAGDILALVFGLLFAVTSVAFLV	QMRRQHRRGT
128	P27824	MEGKWLLCMLLVLGT...EILNRSPRNRKPRRE	2	483	505	MIEAAEERPW	LWVVYILTVALPVFLVILFCCSG	KKQTSGMEYK
129	O75976	MASGRDERPPWRLGR...DETDTEEETLYSSKH	2	1300	1322	DNRIFGLPRE	LVVTVSGATMSALILTACIIWCI	CSIKSNRHKD
130	Q13740	MESKGASSCRLLFCL...EENKKLEENNHKTEA	2	528	550	NREKVNDQAK	LIVGIVVGLLLAALVAGVVYWLY	MKKSKTASKH
131	P15391	MPPPRLLFFLLFLTP...PAWGGGGRMGTWSTR	2	295	317	LRTGGWKVSA	VTLAYLIFCLCSLVGILHLQRAL	VLRRKRKRMT
132	P29017	MLFLQFLLLALLLPG...LVLWFKKHCSYQDIL	2	301	323	DIILYWGHHF	SMNWIALVVIVPLVILIVLVLWF	KKHCSYQDIL
133	P11609	MRYLPWLLLWAFLQV...VYYIWRRRSAYQDIR	2	304	326	ILYWDARQAP	VGLIVFIVLIMLVVVGAVVYYIW	RRRSAYQDIR
134	P15813	MGCLLFLLLWALLQA...FTSRFKRQTSYQGVL	2	299	321	QDIVLYWGGS	YTSMGLIALAVLACLLFLLIVGF	TSRFKRQTSY
135	P15812	MLLLFLLFEGLCCPG...NRVLKKWKTRLNQLW	2	303	325	GGHDLIIHWG	GYSIFLILICLTVIVTLVILVVV	DSRLKKQSSN
136	Q15762	MDYPTLLLALLHVYR...YVNYPTFSRRPKTRV	2	253	275	GKTDNQYTLF	VAGGTVLLLLFVISITTIIVIFL	NRRRRRERRD
137	P20273	MHLLGPWLLLLVLEY...RPQAQENVDYVILKH	2	684	706	TLTVYYSPET	IGRRVAVGLGSCLAILILAICGL	KLQRRWKRTQ
138	Q07763	MLGQAVLFTTFLLLR...ARLSRRELENFDVYS	2	226	248	QSVPSNFRFL	PFGVIIVILVTLFLGAIICFCVW	TKKRKQLQFS
139	Q9HCU0	MLLRLLLAWAAAGPT...PRGSLTGVQTCRTSV	2	686	708	LAEHSQRDDR	WLLVALLVPTCVFLVVLLALGIV	YCTRCGPHAP
140	Q5ZPR3	MLRRRGSPGMGVHVG...LKHSDSKEDDGQEIA	2	466	488	TGQPMTFPPE	ALWVTVGLSVCLIALLVALAFVC	WRKIKQSCEE
141	P26842	MARPHPWWLCVLGTL...PIQEDYRKPEPACSP	2	189	211	PPQRSLCSSD	FIRILVIFSGMFLVFTLAGALFL	HQRRKYRSNK
142	P10747	MLRLLLALNLFPSIQ...YQPYAPPRDFAAYRS	2	154	176	PLFPGPSKPF	WVLVVVGGVLACYSLLVTVAFII	FWVRSKRSRL
143	P06729	MSFPCKFVASFLLIF...PPHGAAENSLSPSSN	2	212	234	SCPEKGLDIY	LIIGICGGGSLLMVFVALLVFYI	TKRKKQRSRR
144	Q8IX05	MLRAALPALLLPLLG...VLVVGEENEYPVQFD	2	171	193	RKYLSDNHIL	ISALVIASTVILTVLGAIIWFLY	KKHSDSRFTT
145	Q9NPF0	MSGGWMAQVGAWRTG...MKESLLLSEQKTSLP	2	231	253	DQSGSPTAYG	VIAAAAVLSASLVTATLLLLSWL	RAQERLRPLG
146	P28906	MLVRRGARAGPRMPR...NGHSARQHVVADTEL	2	291	313	ASHQSYSQKT	LIALVTSGALLAVLGITGYFLMN	RRSWSPTGER
147	P04235	MEHSGILASLILIAV...QYSRLGGNWPRNKKS	2	105	127	NCVELDSGTM	AGVIFIDLIATLLLALGVYCFAG	HETGRPSGAA
148	P07766	MQSGTHWRVLGLCLL...KGQRDLYSGLNQRRI	2	130	152	ENCMEMDVMS	VATIVIVDICITGGLLLLVYYWS	KNRKAKAKPV
149	P09693	MEQGKGLAVLILAII...DDQYSHLQGNQLRRN	2	115	137	QNCIELNAAT	ISGFLFAEIVSIFVLAVGVYFIA	GQDGVRQSRA
150	P20963	MKWKALFTAAILQAQ...KDTYDALHMQALPPR	2	31	53	AQSFGLLDPK	LCYLLDGILFIYGVILTALFLRV	KFSRSADAPA
151	P01730	MNRGVPFRHLLLVLQ...TCQCPHRFQKTCSPI	2	398	420	PTWSTPVQPM	ALIVLGGVAGLLLFIGLGIFFCV	RCRHRRRQAE
152	P30203	MWLFFGITGLLTAAL...PDSTDNDDYDDISAA	2	402	424	ENKESRELML	LIPSIVLGILLLGSLIFIAFILL	RIKGKYALPV
153	P11912	MPGGPGVLQALPATI...DVGSLNIGDVQLEKP	2	143	165	FLDMGEGTKN	RIITAEGIILLFCAVVPGTLLLF	RKRWQNEKLG
154	P40259	MARLALSPVPSHWMV...TGEVKWSVGEHPGQE	2	161	180	LKQRNTLKDG	IIMIQTLLIILFIIVPIFLL	LDKDDSKAGM
155	P50283	MTQQAVLALLLTLAG...SYSNRKTPCIPNQYQ	2	149	171	SQEPLQTSFS	FPAAIAVGFFFTGLLLGVVCSML	RKIQIKKLCA
156	P33681	MGHTRRQGTSPSKCP...RRRNERLRRESVRPV	2	247	269	EHFPDNLLPS	WAITLISVNGIFVICCLTYCFAP	RCRERRRNER
157	Q00609	MACNCQLMQDTPLLK...TFGPEEALAEQTVFL	2	249	271	EDPPDSKNTL	VLFGAGFGAVITVVVIVVIIKCF	CKHRSCFRRN
158	Q01151	MSRGLQLLLLSCAYS...NKHLGLVTPHKTELV	2	146	168	ETFKKYRAEI	VLLLALVIFYLTLIIFTCKFARL	QSIFPDFSKA
159	P42081	MDPQCTMGLSNILFV...KSSKTSSCDKSDTCF	2	246	268	LEDPQPPPDH	IPWITAVLPTVIICVMVFCLILW	KWKKKKRPRN
160	P42082	MDPRCTMGLAILIFV...KELEPQIASAKPNAE	2	246	263	FPSPQTYWKE	ITASVTVALLLVMLLIIV	CHKKPNQPSR
161	P01732	MALPVTALLLPLALL...VVKSGDKPSLSARYV	2	184	206	TRGLDFACDI	YIWAPLAGTCGVLLLSLVITLYC	NHRNRRRVCK
162	Q9BYE9	MAQLWLSCFLLPALV...EGPSYTNAGLDTTDL	2	1155	1177	ESDLSKQLIS	VIIGLGVALLLVLVIMTMAFVCV	RKSYNRKLQA
163	Q6ZTQ4	MQEAIILLALLGAMS...PAFMNRAYPKPHPGK	2	710	732	LRKNVYSPSA	WYVPFVITLGSILLLGLLVYLVV	LLAKAIHRHC
164	A6H8M9	MVLLRLLVFLFAPVV...RDYLFNTHTGARRWL	2	686	708	TDTEAFWQPQ	PWFVVVLTATGALLLLALGWLLG	RLLQGLAQLL
165	Q9HBB8	MGSWALLWPPLLFTG...GGGPYDAPGGDDSYI	2	668	690	SEDKRFSVVD	MAALGGVLGALLLLALLGLAVLV	HKHYGPRLKC
166	Q9D871	MDFSRPSFSPWRWLT...CSRGKTCHKCPWQTN	2	334	356	TVNRELYIPG	PLVIFLILLTSLGGAFVCRVLVY	SLFQSCSRGK
167	P13688	MGHLSAPLHRVRVPW...SLTATEIIYSEVKKQ	2	433	455	NGLSPGAIAG	IVIGVVALVALIAVALACFLHFG	KTGRASDQRD
168	Q925P2	MELASAHLHKGQVPW...SPRATETVYSEVKKK	2	422	444	VIFDSTYDIS	DVPIAVIITGAVAGVILIAGLAY	RLCSRKSRWG
169	Q6ZU64	MFTLTGCRLVEKTQK...AEVLHPVVPLPTDLP	2	187	209	KMKYRPPKTK	FFFTVIPQPIFLSPGITLTLPIV	FRPLEAKEYM
170	Q9H9P2	MSRVVSLLLGAALLC...LWISKSTRKESGMEV	2	218	240	VTEAGIIPNL	IYVVIPTIPLLLLILVAFGTCCF	QMLHKSKGRT
171	Q96F05	MWTALVLIWIFSLSL...QVDYLINGMYADSEM	2	400	422	EPLTQAVVDK	TLLLVVLLLGVTLFITVLVLFAL	QAYESYKKKD
172	Q6NUJ2	MSARAPKELRLALPP...LDTAGEGLLQTVVLS	2	62	84	QQLFQSFSST	LVLIVLVTLIFCLIVLSLSTFHI	HKRRMKKRKM
173	Q86T13	MRPAFALCLLWQALW...EGALLAESPLGSSDA	2	399	421	PQAFDSSSAV	VFIFVSTAVVVLVILTMTVLGLV	KLCFHESPSS
174	Q8BG22	MTHRDSTGPVIGLKL...RKKRPSRKENETKFL	2	904	926	VVSRDDLILK	GVLTTVGLIAILCLIMVVAHCIF	NRKKRPSRKE
175	O14967	MHFQAFWLCLGLLFI...DGPIKSVRKRRVRKD	2	471	493	QLMAAAEGHP	WLWLIYLVTAGVPIALITSFCWP	RKVKKKHKDT
176	Q8TDQ1	MPLLTLYLLLFWLSG...RGPEEPTEYSTISRP	2	156	178	LDNRHKLLKL	SVLLPLIFTILLLLLVAASLLAW	RMMKYQQKAA
177	Q08708	MTARAWASWRSSALL...RSSRSRQNWPKGENQ	2	184	206	HPGSLFSNVR	FLLLVLLELPLLLSMLGAVLWVN	RPQRSSRSRQ
178	A8K4G0	MWLPPALLLLSLSGC...IYMNFSEPLTKDMAT	2	150	172	AVFIGSHKRN	HYMLLVFVKVPILLILVTAILWL	KGSQRVPEEP
179	Q9H6B4	MSLLLLLLLVSYYVG...TPSMIPSQSRAFQTV	2	234	256	TVQYVQSIGM	VAGAVTGIVAGALLIFLLVWLLI	RRKDKERYEE
180	Q9BZ76	MASVAWAVLKVLLLL...LRKENESKVSKKEEC	2	1244	1266	EPLVNADRRD	SAVIGGVIAVVIFILLCITAIAI	RIYQQRKLRK
181	Q6NT55	MLPITDRLLHLLGLE...ENGLWLKVEPLPPRA	2	21	40	LLGLEKTAFR	IYAVSTLLLFLLFFLFRLLL	RFLRLCRSFY
182	P17927	MGASSPRSPEPVGPP...PRTLQTNEENSRVLP	2	1974	1996	KCTSRTHDAL	IVGTLSGTIFFILLIIFLSWIIL	KHRKGNNAHE
183	P20023	MGAAGLLGVFLALVA...EAREVYSVDPYNPAS	2	976	998	AVCRSRSLAP	VLCGIAAGLILLTFLIVITLYVI	SKHRARNYYT
184	Q9NZV1	MYLVAGDRGLAGCGH...QKQNHLQADNFYQTV	2	939	961	LHPSEDSSLD	SIASVVVPIIICLSIIIAFLFIN	QKKQWIPLLC
185	Q9HC73	MGRLVLLWGAAVFLL...GGFTFVMNDRSYVAL	2	233	252	TPPKPKLSKF	ILISSLAILLMVSLLLLSLW	KLWRVKKFLI
186	O95727	MWWRVLSLLAWFPLQ...SKLEEKHIQVPESIV	2	288	310	YLGLARKKSG	ILLLTLVSFLIFILFIIVQLFIM	KLRKAHVIWK
187	Q8VHS2	MKLKRTAYLLFLYLS...EMWIRMPPPALERLI	2	1346	1368	ADDRLLGIFT	AVGSGTLALFFILLLAGVASLIA	SNKRATQGTY
188	Q5IJ48	MALARPGTPDPQALA...EMDSVLKVPPEERLI	2	1225	1247	PLPLPFPLLE	VAVPAACACLLLLLLGLLSGILA	ARKRRQSEGT
189	Q9BUF7	MANPGLGLLLALGLP...PPTPNLKLPPEERLI	2	57	79	SSDGNLRPEA	ITAIIVVFSLLAALLLAVGLALL	VRKLREKRQT
190	Q8NEA5	MDKVQSGFLILFLFL...NKTKNASHNGKMEDL	2	102	124	IRHRPALVKV	ILISSVAFSIALICGMAISYMIY	RLAQAEERQQ
191	P07333	MGPGVLLLLLVATAW...DIAQPLLQPNNYQFC	2	515	537	AHTHPPDEFL	FTPVVVACMSIMALLLLLLLLLL	YKYKQKPKYQ
192	P15509	MLLLVTSLLLCELPH...GKGYREEVLTVKEIT	2	324	346	EFGSDDGNLG	SVYIYVLLIVGTLVCGIVLGFLF	KRFLRIQRLF
193	Q99062	MARLGNCSLTWAALI...LQGIRVHGMEALGSF	2	626	648	LMTLTPEGSE	LHIILGLFGLLLLLTCLCGTAWL	CCSPNRKNPL
194	Q96PZ7	MTAWRRFQSLLLLLG...AVRFDTTLNTVCTVV	2	3487	3509	SSHYHGTSSG	SVAAAILVPFFALILSGFAFYLY	KHRTRPKVQY
195	O95196	MGRAGGGGPGRGPPP...DQADLDVNCLQNNLT	2	421	443	RCESIITDFQ	VMCVAVGSAALVLLLLFMMTVFF	AKKLYLLKTE
196	P16410	MACLGFQRHKAQLNL...PECEKQFQPYFIPIN	2	162	184	IDPEPCPDSD	FLLWILAAVSSGLFFYSFLLTAV	SLSKMLKKRS
197	Q86XM0	MLMLMLVAAVTMWLR...PPGRHRTPHGGRSDH	2	719	741	IYVYGAFPVQ	LVSAGVVILLIISSILGSVWLAY	KTPKLLRTAR
198	E9Q9F6	MLVLMLAAAVATMVR...QNRGKVRVAQKHPET	2	755	777	KQLRSEKGQR	LLGFCYQILQLCLGVCFCTWLRG	KLRQWLRPRR
199	Q5SY80	MSAREVAVLLLWLSC...IYEPLHKPQRKRKKN	2	905	927	TFGLIPSPSV	YLVASFLFVLMLLFFTILVLSYF	RYMRIYRRYI
200	Q6ZRH7	MCGPAMFPAGPPWPR...DRAEPKEAVERQLMT	2	1073	1095	PKRALFIIMV	SASVFVGLVIFYIAFCLLWPLVV	KGCTMIRWKI
201	Q86UP6	MELVRRLMPLTLLIL...VNQRADYKYQKLQNY	2	571	593	TPNQPFNSVH	LFSFMVLALNVVTVATITVRHFV	NQRADYKYQK
202	Q5JRM2	MNLVICVLLLSIWKN...DRGYNQVTSEVTLND	2	48	70	QTKLNYLRRN	LLILVGIIIMVFVFICFCYLHYN	CLSDDASKAG
203	Q96J86	MDAPRLPVRPGVLLP...AQRSPPPPYPGNARK	2	63	85	YIGNILSGTA	IAGIVFGIVFIMGVIAGIAICIC	MCMKNHRATR
204	Q61476	MVSSTWGYDPRAGAG...RRSDFQGKERKDVSK	2	367	389	ESNSGGDRYI	YGFVAVIAMIDSLIIVKTLWTIL	SPNRRSDFQG
205	Q8N8Z6	MVPGARGGGALARAA...DCLTPLNQTAMTALL	2	458	480	EETSTGINIT	TVAIPLVLLVVLVFAGMGIFAAF	RKKKKKGSPY
206	Q96PD2	MASRAVVRARRCPQC...GAGRDGECDVFKEIL	2	527	549	TTVTPNVTKD	VALAAVLVPVLVMVLTTLILILV	CAWHWRNRKK
207	Q16832	MILIPRMLLVLFLLL...SFQEIHLLLLQQGDE	2	399	421	PMLKVDDSNT	RILIGCLVAIIFILLAIIVIILW	RQFWQKMLEK
208	P80370	MTATEALLRVLLLLL...IDMTTFSKEAGDEEI	2	305	327	KTPLLTEGQA	ICFTILGVLTSLVVLGTVGIVFL	NKCETWVSNL
209	Q6UY11	MPSGCRCLHLVCLLC...LPRDLPPEPGKTTAL	2	307	329	RQEAGLGEPS	LVALVVFGALTAALVLATVLLTL	RAWRRGVCPP
210	P28068	MITFLPLLLGLSLGC...TPLPGSNYSEGWHIS	2	219	238	PGLSPMQTLK	VSVSAVTLGLGLIIFSLGVI	SWRRAGHSSY
211	Q96KC8	MTAPCSQPAQLPGRR...KLLVELVQKKKQAKS	2	153	175	YRRVRKMSNA	ELALLLFIILTVGHYAVVWSIYL	EKQLDELLSR
212	P20036	MRPEDRMFHIRAVIL...KSLRSGHDPRAQGTL	2	223	245	EPIQMPETTE	TVLCALGLVLGLVGIIVGTVLII	KSLRSGHDPR
213	P01903	MAISGVPVLGFFIIA...KGLRKSNAAERRGPL	2	217	239	APSPLPETTE	NVVCALGLTVGLVGIIIGTIFII	KGLRKSNAAE
214	P13762	MVCLKLPGGSCMAAL...NQKGHSGLQPTGLLS	2	228	250	SARSESAQSK	MLSGVGGFVLGLLFLGTGLFIYF	RNQKGHSGLQ
215	Q08554	MALASAAPGSIFCKQ...LEPKFRTLAKTCIKK	2	692	714	DVRPNVILGR	WAILAMVLGSVLLLCILFTCFCV	TAKRTVKKCF
216	Q19T08	MGTAGAMQLCWVILG...NMNNGKQSLSAEKVL	2	123	145	SPTSETVLTV	AAFGVISFIVILVVVVIILVGVV	SLRFKCRKSK
217	Q9UNE0	MAHVGDCTQTPWLPV...WAGVVPPASQPHAAS	2	188	210	LSGQGHLATA	LIIAMSTIFIMAIAIVLIIMFYI	LKTKPSAPAC
218	P00533	MRPSGTAGAALLALL...EYLRVAPQSSEFIGA	2	646	668	CPTNGPKIPS	IATGMVGALLLLLVVALGIGLFM	RRRHIVRKRT
219	P01133	MLLTLIILLPVVSKF...QQRALDPPHQMELTQ	2	1033	1055	RHAGHGQQQK	VIVVAVCVVVLVMLLLLSLWGAH	YYRTQKLLSK
220	Q6UXG2	MAEPGHSHHLSARVR...SVPLKTSSGGLDMDL	2	908	930	RVTICKTIDF	WLKVGISAGTCTAILLTVLTCYF	WKKNQKLEYK
221	P0C7U0	MAGRGWGALWVCVAA...DILDYWKGVSAQHKS	2	418	440	PVPSPSTATH	YIMTILGCLFGMVLVLGAVYYCL	RRRRRQEEKH
222	Q6PCB8	MRALPGLLEARARTP...ENNVPRHRKNESLGQ	2	264	281	VLSYLVPLKP	FLVIVAEVILLVATILLC	EKYTQKKKKH
223	Q5UCC4	MAAASAGATRLLLLL...QGGGGGGGGGGGSGR	2	221	243	QKAKNPQEQK	SFFAKYWMYIIPVVLFLMMSGAP	DTGGQGGGGG
224	Q9NPA0	MAAALWGFFPVLLLL...SGSSKTGKSGAGKRR	2	160	182	IKRESWGWTD	FLMNPMVMMMVLPLLIFVLLPKV	VNTSDPDMRR
225	Q902F9	MNPSEMQRKAPPRRR...NVGKSKRDQIVTVSV	2	633	655	NLNTVTWVKT	IGSTTIINLILILVCLFCLLLVY	RCTQQLRRDS
226	Q9Y6X5	MKLLVILLFSGLITG...SRLQLQEDDDDPLIG	2	406	428	LVDQWCINLP	EAIAIVIGSLLVLTMLTCLIIIM	QNRLSVPRPF
227	Q6UW88	MALGVPISVYLLFNA...LKSPYNVCSGERRPL	2	111	133	TSYAVDSYEK	YIAIGIGVGLLLSGFLVIFYCYI	RKRCLKLKSP
228	Q60750	MERRWPLGLALLLLL...GHQKRILCSIQGFKD	2	549	571	PVSRSLTGGE	IVAVIFGLLLGIALLIGIYVFRS	RRGQRQRQQR
229	Q9UF33	MGGCEVREFLLQFGF...LRLHMMHIQEKGFHV	2	549	571	SDMAAEQGQI	LVIATAAVGGFTLLVILTLFFLI	TGRCQWYIKA
230	P29322	MAPARGRLPPALWVV...MRAQLTSTQGPRRHL	2	541	563	TGKPRPRYDT	RTIVWICLTLITGLVVLLLLLIC	KKRHCGYSKA
231	P19235	MDHLGASLWPQVGSL...IPAAEPLPPSYVACS	2	251	273	SLLTPSDLDP	LILTLSLILVVILVLLTVLALLS	HRRALKQKIW
232	Q9NQ60	MNFILFIFIPGVFSL...GSDNEMHENDESVTR	2	184	206	DLEDLKIKIM	LGISLMTLLLFVVLLAFCSATLY	KLRHLSYKSC
233	P04626	MELAALCRWGLLLAL...PTAENPEYLGLDVPV	2	653	675	PAEQRASPLT	SIISAVVGILLVVVLGVVFGILI	KRRQQKIRKY
234	P21860	MRANDALQVLGLLFS...YWHSRLFPKANAQRT	2	644	666	LVLIGKTHLT	MALTVIAGLVVIFMMLGGTFLYW	RGRRIQNKRA
235	O14944	MTAGRRMEMLCAGRV...EYERVTSGDPELPQV	2	118	140	LTVHQPLSKE	YVALTVILIILFLITVVGSTYYF	CRWYRNRKSK
236	Q925F2	MILQAGTPETSLLRV...VPVMVPAQSQAGSLV	2	252	274	LDVMTGSKAA	VVAGAVVGTFVGLVLIAGLVLLY	QRRSKTLEEL
237	P58658	MLLPGRARQPPTPQP...SGLDTSLPRNMGQFY	2	322	344	FAYIRAHPER	AALLFVSSVCIGLALTLCALVIR	ESCAKDFRDL
238	P22794	MPTDMEHTGHYLHLA...KDEEGTEKLTNKQIG	2	136	158	CAENNNNMAM	LICLIIIAVLFLICTFLFLSTVV	LANKVSSLRR
239	P34910	MDPKYFILILFCGHL...QDLNESLPPPPAELL	2	203	225	QTPQKNNYNS	IAAILIGVLLTSMLVAIIIIVLW	KCLRKPVLND
240	Q6P995	MARLCRRVPCTLLLG...NIWKKREERPLIPIN	2	353	375	EDSKDITAYH	TVFLTAILGGTIVIVIGFFAVLL	CYCRDKCGTP
241	Q8TBP5	MKASQCCCCLSHLLA...EDDDNTLFDANHPRR	2	124	146	NPGDKPMTQR	ALTVLMVVSGAVLVYFVVRTVRM	RRRNRKTRRY
242	Q3ZCQ3	MRAVPLPAPLLPLLL...DDEDEDSTVFDIKYR	2	93	115	ILLRDLPTLK	AAVIVAFAFTTLLIACLLLRVFR	SGKRLKKTRK
243	Q9BVV8	MGPRVLQPPLLLLLL...LDSDEETVFESRNLR	2	74	93	GASGSALTRS	FYVILGFCGLTALYFLIRAF	RLKKPQRRRY
244	Q9D3R5	MSLAHTTVLLWAWGS...CQSRCCPNFSAQTLL	2	377	399	PASLSDPETR	TAIELTLMGYLLITIFFITIHLC	RCCCQSRCCP
245	Q17R55	MPPMLWLLLHFAAPA...HPSPGRRSTQVLVVK	2	329	351	ARKALRGRAD	SVLKGLKLVLLVVTVLALLGALL	KCIHPSPGRR
246	Q15884	MILLVNLFVLLSVVC...ERPHSLIGVIRETVL	2	86	108	CSAVHLLLKK	VLFALCALNALTTTVCLVAAALR	YLQIFATRRS
247	Q5JX71	MWTLKSSLVLLLCLT...YHVTICEIWGEESSS	2	51	73	HFRIRQNLPE	HTQGWLGSKWLWLLFVVVPFVIL	QCQRDSEKNK
248	Q14517	MGRHLALLLLLLLLF...EVTIPPLDSQQHTEV	2	4179	4201	QYVSTPWNIG	LAEGIGIVVFVAGIFLLVVVFVL	CRKMISRKKK
249	Q9NYQ8	MTIALLGFAIFLLHC...DMVESDYGSCEEVMF	2	4049	4071	IQRGDWGQQE	LLIITVAVAFIIISTVGLLFYCR	RCKSHKPVAM
250	Q8TDW7	MDIIMGHCVGTRPPA...SLHIPFVETQHQTQV	2	4156	4175	GHSYVGKEEL	IGIAVVLFVIFILVVLFIVF	RKKVFRKNYS
251	Q8WWV6	MPLFLILCLLQGSSF...PAGASLTAPERNPGP	2	451	470	TFPEDESSSR	TLAPVSTMLALFMLMALVLL	QRKLWRRRTS
252	P12319	MAPAMESPTLLCVAL...FRLLNPHPKPNPKNN	2	203	225	TVIKAPREKY	WLQFFIPLLVVILFAVDTGLFIS	TQQQVTFLLK
253	P12318	MTMETQMSQNVCPRN...IYLTLPPNDHVNSNN	2	218	240	PSMGSSSPMG	IIVAVVIATAVAAIVAAVVALIY	CRKKRISANS
254	P08637	MWQLLLPTALLLLVS...WKDHKFKWRKDPQDK	2	207	229	STISSFFPPG	YQVSFCLVMVLLFAVDTGLYFSV	KTNIRSSTRD
255	P12314	MWFLTTLLLWVPVDG...QLQEGVHRKEPQGAT	2	289	311	QVLGLQLPTP	VWFHVLFYLAVGIMFLVNTVLWV	TIRKELKRKK
256	P55899	MGVPRPQPWALGLLL...QDADLKDVNVIPATA	2	298	320	VELESPAKSS	VLVVGIVIGVLLLTAAAVGGALL	WRRMRSGLPA
257	Q96LA6	MLPRLLLLICAPLCE...LRKANITDVDYEDAM	2	308	330	TGARSNHLTS	GVIEGLLSTLGPATVALLFCYGL	KRKIGRRSAR
258	Q96LA5	MLLWSLLVIFDAVTE...ENKDSQVIYSSVKKS	2	400	422	DGYRRDLMTA	GVLWGLFGVLGFTGVALLLYALF	HKISGESSAT
259	Q96P31	MLLWLLLLILTPGRE...ENYENVPRVLLASDH	2	572	594	VTGTSRNRTG	LTAAGITGLVLSILVLAAAAALL	HYARARRKPG
260	Q68SN8	MSGSFSPCVVFTQMW...ESESPRSRCQMAEKK	2	495	517	FDMTKNRSVP	MAAGITVGLLIMAVGVFLFYCWF	SRKAGGKPTS
261	Q6DN72	MLLWTAVLLFVPCVG...RTLQEPLSDCEEVLC	2	307	329	SQVLFTPASN	WLVPWLPASLLGLMVIAAALLVY	VRSWRKAGPL
262	P11362	MWSWKCLLFWAVLVT...PRHPAQLANGGLKRR	2	375	397	RPAVMTSPLY	LEIIIYCTGAFLISCMVGSVIVY	KMKSGTKKSD
263	Q8N441	MTPSPLLLLLLPPLL...SHVEGKVHQHIHYQC	2	377	399	ASSSSATSLP	WPVVIGIPAGAVFILGTLLLWLC	QAQKKPCTPA
264	P36888	MPALARDGGQLPLLV...MDLGLLSPQAQVEDS	2	542	564	PGPFPFIQDN	ISFYATIGVCLLFIVVLTLLICH	KYKKQFRYES
265	F2Z333	MRAPPLLLLLAACAP...LMRPALARPGLRRHP	2	183	205	FTAEPAGMQD	IVVAMTAVGGSICVMLVVICLLV	AYITENLMRP
266	Q8NAU1	MHPGSPSAWPPRARA...STPEHQGGGLLRSKI	2	150	172	TMKEMGRNQQ	LRTGEVLIIVVVLFMWAGVIALF	CRQYDIIKDN
267	Q9P2B2	MGRLASRPLLLALLS...ETRRERRRLMSMEMD	2	831	853	VKMDVLNAFK	YPLLIGVGLSTVIGLLSCLIGYC	SSHWCCKKEV
268	Q5SZK8	MHSAGTPGLSSRRTG...PMVPPQSHHNDSSEV	2	3111	3133	ELNSPSSAVS	LVTVVGGTTVGLLTICLTVIAVL	MCRGKESFRG
269	P09958	MELRPWLLWVVAATG...GRGERTAFIKDQSAL	2	716	738	AGLLPSHLPE	VVAGLSCAFIVLVFVTVFLVLQL	RSGFSFRGVK
270	P23188	MELRSWLLWVVAAAG...GRGERTAFIKDQSAL	2	713	735	RLQAGLASHL	PEVLAGLSCLIIVLIFGIVFLFL	HRCSGFSFRG
271	O95866	MAVFLQLLPLLLSRA...TADPADASTIYAVVV	2	143	165	GPTHGSVYPQ	LLIPLLGAGLVLGLGALGLVWWL	HRRLPPQPIR
272	D7PDD4	MALVLPLLPLLLSKV...TVVSGDASTVYAVVV	2	141	160	GSTHGYEYPK	VLIPLLGVGLVLGLGVAGVV	WRRRRLSPPP
273	Q9NU53	MEGAPPGSLALRLLL...GPEKRAENLEDKTCI	2	262	284	LCRFWSNVFP	VFFQFLNIMVVGITGAAVVITIL	KVFFPVSEYK
274	Q8WWB7	MRGSVECTWGWGHCA...LLLHHKKYSEYQSIN	2	372	394	PVDGLSPLVL	GIMAVALGAPGLMLLGGGLVLLL	HHKKYSEYQS
275	P02724	MYGKIIFVLLLSEIV...PLSSVEIENPETSDQ	2	92	114	QLAHHFSEPE	ITLIIFGVMAGVIGTILLISYGI	RRLIKKSPSD
276	Q86XS8	MSCAGRAGPARLAAL...IRATASLNANEVEWF	2	195	217	MPPKNFSRGS	LVFVSISFIVLMIISSAWLIFYF	IQKIRYTNAR
277	P07359	MPLLLLLLLLPSPLH...DLLSTVSIRYSGHSL	2	533	555	PDFCCLLPLG	FYVLGLFWLLFASVVLILLLSWV	GHVKPQALDS
278	Q99795	MVGKMWPVLWTLCAV...EQRSTGRESPDHLDQ	2	235	257	TVAVRSPSMN	VALYVGIAVGVVAALIIIGIIIY	CCCCRGKDDN
279	Q14956	MECLYYFLGFLLLAA...EKDPLLKNQEFKGVS	2	497	519	DRDPASPLRM	ANSALISVGCLAIFVTVISLLVY	KKHKEYNPIE
280	P40197	MLRGTLLCAVLGLLR...IGQLFRKLIRERALG	2	522	544	TGKGQDHSPF	WGFYFLLLAVQAMITVIIVFAMI	KIGQLFRKLI
281	P25092	MKTLLLDLALWSLLF...EYLQLNTTDKESTYF	2	432	454	NDITGRGPQI	LMIAVFTLTGAVVLLLLVALLML	RKYRKDYELR
282	Q02846	MTACARRAGGLPDPG...ERRRKLEKARPGQFS	2	465	487	NICGGGLEPG	LVFLGFLLVVGMGLAGAFLAHYV	RHRLLHMQMV
283	A0A0U1RPR8	MAGLQQGCHFEGQNW...GLAEPRKSGEAGPGP	2	480	502	CIRGVQPLGS	LLTLTIACVLALVGGFLAYFIRL	GLQQLRLLRG
284	P51841	MFLGLGRFSRLVLWF...FQRRKAERQLVRNKP	2	468	490	KICHGGIDPA	FAMMVCLTLLIALLSINGFAYFI	RRRINKIQLI
285	B1B212	MAKSSLSLNWSLLVL...KKKKGALCCSSSSTT	2	211	233	QHNSDTQGLS	FTWIVIICIGGIVSFMAFMVFAW	CMLKKKKGAL
286	Q8TDQ0	MFSHLPFDCVLLLLL...RQQPSQPLGCRFAMP	2	202	224	LRDSGATIRI	GIYIGAGICAGLALALIFGALIF	KWYSHSKEKI
287	Q99075	MKLLPSVVLKLFLAA...VENEEKVKLGMTNSH	2	162	184	NRLYTYDHTT	ILAVVAVVLSSVCLLVIVGLLMF	RYHRRGGYDV
288	Q9QUJ0	MDPPGYLLFLLLLPV...AQEDGRVYINMPGRG	2	35	57	CSGCGTLSLP	LLAGLVAADAVMSLLIVGVVFVC	MRPHGRPAQE
289	A8MVW5	MGQDAFMEPFGDTLG...EVIQHIPAQQQDHPE	2	350	372	EKLAQKGKSL	SPLASITGISLFLIISMCLLFLW	KKYQPYKVIK
290	Q14CZ8	MKRERGALSRASRAL...IIREQDEAGPVEISA	2	241	263	VKITVYRRSS	LYIILSTGGIFLLVTLVTVCACW	KPSKRKQKKL
291	E9Q7X6	MATPRAPRWPPPSLL...NPSFISDESRRRDYF	2	1204	1226	GGLNCGNPYQ	LITVVIAAAGGGLLLILGVALIV	TCCRKSKNDI
292	Q9BQS7	MESGHLLWALLFMQS...RSILDDSFKLLSFKQ	2	1110	1132	IPIKNVEMLA	SVLVAISVTLLLVVLALGGVVWY	QHRQRKLRRN
293	Q9UM44	MKAQTALSFFLILIT...APDNGEENVPLSGKV	2	346	365	PSQETASHNK	GLWILVPSAILAAFLLIWSV	KCCRAQLEAR
294	Q75VT8	MPWTILLFASGSLAI...SSPEPPEFSTFRACQ	2	123	145	QVSFPVPTWI	LALSLSLAGAVLFSGLVAITVLV	RKAKAKNLQK
295	Q8HWB0	MMLLLPLLAVFLVKR...VMYQPTQVNEGSSPS	2	297	319	APRESGDILR	VSTISGTTILIIALAGVGVLIWR	RSQELKEVMY
296	Q6MZM0	MPRKQPAGCIFLLTF...DYQQVQSCALPTDAL	2	1115	1137	KNLGPTGAKA	ALVILFIIGLLLLITTVILSLRL	CSAMKQTDYQ
297	Q08334	MAWSLGSWLGGCLLV...DSCSLGTPPGQGPQS	2	224	246	HDETVPSWMV	AVILMASVFMVCLALLGCFALLW	CVYKKTKYAF
298	Q64385	MSSSCSGLTRVLVAV...LPGIPNLQRTPENFS	2	369	391	LDHRDPLEQV	AVLASLGIFSCLGLAVGALALGL	WLRLRRSGKD
299	P42701	MEPLVTWVVPLLFLF...TELSLEDGDRCKAKM	2	546	568	RFSIEVQVSD	WLIFFASLGSFLSILLVGVLGYL	GLNRAARHLC
300	Q99665	MAHTFRGCSLAFMFI...LTLDQLKMRCDSLML	2	623	645	REFCLQGKAN	WMAFVAPSICIAIIMVGIFSTHY	FQQKVFVLLA
301	Q14627	MAFVCLAIGCLYTFL...PNTYPKMIPEFFCDT	2	344	363	EDLSKKTLLR	FWLPFGFILILVIFVTGLLL	RKPNTYPKMI
302	O88786	MAFVHIRCLCFILLC...VDLNKEVCAYEDTLC	2	335	357	WEGYTGPDSK	IIFIVPVCLFFIFLLLLLCLIVE	KEEPEPTLSL
303	Q60819	MASPQLRGYGVQAIP...MTVRASSKEDEDTGA	2	206	228	ISPHSSKMTK	VAISTSVLLVGAGVVMAFLAWYI	KSRQPSQPCR
304	Q96F46	MGAARSPPSAVPGPL...SGWDTMGSESEGPSA	2	319	341	TPEPIPDYMP	LWVYWFITGISILLVGSVILLIV	CMTWRLAGPG
305	Q8NAC3	MPVPWFLLSLALGRS...RGVGPGAGPGAGDGT	2	540	559	PMDKYIHKRW	ALVWLACLLFAAALSLILLL	KKDHAKGWLR
306	Q8BH06	MGSPRLAALLLSLPL...DYQGSTNSPCGFSCL	2	415	437	VLCPDVSHRH	LGLLILALLALTALVGVVLVLLG	RRLLPGSGRT
307	O95256	MLCLGWIFLWLVAGE...SRTETTGRSSQPKEW	2	360	382	VQLKEKRGVV	LLYILLGTIGTLVAVLAASALLY	RHWIEIVLLY
308	Q6PHB0	MHTPGTPAPGHPDPP...TRFMEEWGLHVQMES	2	255	277	VQTSAWKAKV	IFWYVFLTSVIVFLFSAIGYLVY	RYIHVGKEKH
309	Q6UXL0	MQTFTMVLEEIWTSL...TAVMSPEELLRAWIS	2	233	255	CVEVQGEAIP	LVLALFAFVGFMLILVVVPLFVW	KMGRLLQYSC
310	Q8N6P7	MRTLLTILTVGSLAA...DSLFRGLALTVQWES	2	227	249	CRVKTLPDRT	WTYSFSGAFLFSMGFLVAVLCYL	SYRYVTKPPA
311	Q6UWB1	MRGGRGAPFWLWPLP...EELGLLGPPRPQVLA	2	517	539	HLPDNTLRWK	VLPGILFLWGLFLLGCGLSLATS	GRCYHLRHKV
312	P05362	MAPSSPRPALPALLV...QKGTPMKPNTQATPP	2	481	503	TVNVLSPRYE	IVIITVVAAAVIMGTAGLSTYLY	NRQRKIKKYR
313	P35330	MSSFACWSLSLLILF...AAWRRLPRAFRARPV	2	224	246	VYEPMQDNQM	VIIIVVVSILLFLFVTSVLLCFI	FGQHWHRRRT
314	O75144	MRLGSPGLLFLLFSS...GAWAVSPETELTGHV	2	254	276	ENPVSTGEKN	AATWSILAVLCLLVVVAVAIGWV	CRDRCLQHSY
315	Q9JHJ8	MQLKCPCFVSLGTRQ...YTGPKTVQLELTDHA	2	280	299	PQETHNNELK	VLVPVLAVLAAAAFVSFIIY	RRTRPHRSYT
316	Q9Y6W8	MKSGLWYFFLFCLRI...AVNTAKKSRLTDVTL	2	142	164	ESQLCCQLKF	WLPIGCAAFVVVCILGCILICWL	TKKKYSSSVH
317	P98153	MVPKADSGAFLLLFL...PGGGRHSRSSLNTVV	2	346	368	DGNSLFDSMA	SGMRLVVSCISSFLILSLLLFMV	HRLRQRRRER
318	Q8IVU1	MAVQRAASPRRPPAP...RPAAARVTQPAHSEQ	2	639	661	KEEAANQTST	TGIVIGIHIGVTCIIFCVLFLLF	GQRGRVLLCK
319	Q9H665	MGPGRCLLTALLLLA...LRVLSKLGSSGVCWA	2	165	187	QQAWPNFLPL	VVLVLLLTLAVIAILLFILLWHL	CWPKEKADPY
320	A8E0Y8	MACILCVASLFLSLT...KTSLQKEAGEESGHY	2	971	993	VSSLICSSGP	LLHFLIVCPFVMLLLLATSFLCL	YRKARKLSQL
321	O75054	MKCFFPVLSCLAVLG...CLEPPVLSIHPGAID	2	1125	1147	LQSIICSNDA	LFYFVFFYPFPIFGILIITILLV	RFKSRNSSKN
322	Q7TSN7	MEGSWRDVLAVLVIL...FDIASPQKVRNVTLV	2	239	261	GEEGPALPTW	AIILLAVAFSLLLILIIVLIIIF	CCCCASRREK
323	O95976	MGTASRSNIARHLQT...NTYENRRVLSNYERP	2	154	176	IKLLSKELRS	FLTALVSLLSVYVTGVCVAFILL	SKSKSNPLRN
324	Q61098	MHHEELILTLCILIV...PWREESEARSVLSAP	2	326	348	IPDIPGHVFT	GGVTVLVLASVAAVCIVILCVIY	KVDLVLFYRR
325	Q9NPH3	MTLLWCVVSLYFYGI...SSDEQGLSYSSLKNV	2	360	382	KVPAPRYTVE	LACGFGATVLLVVILIVVYHVYW	LEMVLFYRAH
326	Q9HBE5	MPRGWAAPLLLLLLQ...VVIPPPLSSPGPQAS	2	233	255	FQTQSEELKE	GWNPHLLLLLLLVIVFIPAFWSL	KTHPLWRLWK
327	Q5VWK5	MNQVTIQWDAVIALY...NILESHFNRISLLEK	2	354	376	GHLTSDNRGD	IGLLLGMIVFAVMLSILSLIGIF	NRSFRTGIKR
328	P14784	MAAPALSWRLPLLIL...LSLQELQGQDPTHLV	2	243	265	PAALGKDTIP	WLGHLLVGLSGAFGFIILVYLLI	NCRNTGPWLK
329	P31785	MLKPSLPFTSLLFLQ...SPYWAPPCYTLKPET	2	262	284	KENPFLFALE	AVVISVGSMGLIISLLCVYFWLE	RTMPRIPTLK
330	Q8NI17	MMWTWALWMLPSLCK...FLVSEKLPEHTKGEV	2	521	543	KTLSFSVFEI	ILITSLIGGGLLILIILTVAYGL	KKPNKLTHLC
331	P26952	MAANLWLILGLLASH...EPALEDCEVTPVTDA	2	333	355	CPPEVMPVKT	ALVTSVATVLGAGLVAAGLLLWW	RKSLLYRLCP
332	P32927	MVLAQGLLSMALLAL...LSLPPWEVNKPGEVC	2	443	465	SWDTESVLPM	WVLALIVIFLTIAVLLALRFCGI	YGYRLRRKWE
333	Q01344	MIIVAHVLLILLGAT...YIEKPGVETLEDSVF	2	342	361	GNDEHKPLRE	WFVIVIMATICFILLILSLI	CKICHLWIKL
334	P40189	MLTLQTWLVQALFIF...SYLPQTVRQGGYMPQ	2	620	642	TPKFAQGEIE	AIVVPVCLAFLLTTLLGVLFCFN	KRDLIKKHIW
335	P16871	MTILGTTFGMVFSLL...QEEAYVTMSSFYQNQ	2	241	263	INNSSGEMDP	ILLTISILSFFSVALLVILACVL	WKKRIKPIVW
336	Q01114	MALGRCIAEGWTLER...LTLAQPVALPVSSRA	2	269	291	RQGLLVPRWQ	WSASILVVVPIFLLLTGFVHLLF	KLSPRLKRIF
337	Q86SU0	MAWPKLPAPWLLLCT...RSEKDSSHSGRSVVI	2	163	185	TSGDPDKEVK	LIVLHWLTVIFIILGALLLLLLI	GVCWCQCCPQ
338	Q01638	MGFWILAILTILMYS...PRKASSLTPLAAQKQ	2	328	350	LSRKNPIDHH	SIYCIIAVCSVFLMLINVLVIIL	KMFWIEATLL
339	Q9BZV3	MIMFPLFGKISLGIL...PEFAAFVREQQVEEV	2	1102	1124	CEEFVSEPVI	IGITIASVVGLLVIFSAIIYFFI	RTLQAHHDRS
340	P17181	MMVVLLGATTLVLVA...ESESKTSEELQQDFV	2	437	459	EKTKPGNTSK	IWLIVGICIALFALPFVIYAAKV	FLRCINYVFF
341	P33896	MLAVVGAAALVLVAG...YLQSPALRTEPALLC	2	427	449	KLCEKTRPGS	FSTIWIITGLGVVFFSVMVLYAL	RSVWKYLCHV
342	P15260	MALLFLLPLVMQGVS...SLIGYRPTEDSKEFS	2	248	270	IFNSSIKGSL	WIPVVAALLLFLVLSLVFICFYI	KKINPLKEKS
343	P38484	MRPTLLWSLLLLLGV...ISFPEKEQEDVLQTL	2	248	270	MADASTELQQ	VILISVGTFSLLSVLAGACFFLV	LKYRGLIKYW
344	Q8IU57	MAGPERWGPLLLCLL...RTEDRGRTLGHYMAR	2	227	249	CFLLEVPEAN	WAFLVLPSLLILLLVIAAGGVIW	KTLMGNPWFQ
345	Q9WTL4	MAVPALWPWGVHLLM...NGASDYSAPNGGPGH	2	922	944	LEEEDTGGMR	IFLTVTPVGFMLLVTLAALGFFY	SRKRNSTLYT
346	Q3MIP1	MSVHYTLNLRVFWPL...PPRSQRTQGFLEGEP	2	46	64	ARAEPADGVD	GGFPLLKVAVLLLLSYVLL	RCRHAVRQRF
347	Q9NZN1	MKAPIPHLILLYATF...LPLLPRETSISSVIW	2	356	378	SVLLHKRELM	YTVELAGGLGAILLLLVCLVTIY	KCYKIEIMLF
348	P26006	MGPGPSRAPRAPRLM...MKSQPSETERLTDDY	2	992	1014	LVEELPAEIE	LWLVLVAVGAGLLLLGLIILLLW	KCGFFKRART
349	P13612	MAWEARREPGPRRAA...RRDSWSYINSKSNDD	2	978	1000	HHQRPKRYFT	IVIISSSLLLGLIVLLLISYVMW	KAGFFKRQYK
350	P20701	MKDSCITVMAMALLS...KPLHEKDSESGGGKD	2	1090	1112	KVDVVYEKQM	LYLYVLSGIGGLLLLLLIFIVLY	KVGFFKRNLK
351	Q3UV74	MLGQCTLLPVLAGLL...HHVEPVWNQERQGTQ	2	672	694	LVCAEISNTT	ILLGVIVGVLLAVIFLLVYCMVY	LKGTQKAAKL
352	A2A863	MAGPCCSPWVKLLLL...SGSLSTHMDQQFFQT	2	711	733	LVHKKKDCPP	GSFWWLIPLLIFLLLLLALLLLL	CWKYCACCKA
353	P26010	MVALPMVLVLLLVLS...TTINPRFQEADSPTL	2	724	746	VRPQEKGADH	TQAIVLGCVGGIVAVGLGLVLAY	RLSVEIYDRR
354	P26012	MCGSALAFFTAAFVC...DISKLNAHETFRCNF	2	682	704	QTSECFSSPS	YLRIFFIIFIVTFLIGLLKVLII	RQVILQWNSN
355	Q8IYV9	MGPHFTLLCAALAGC...QTQVPKEKATDSRQQ	2	291	313	QPLQPEKMLA	SRLLGLLICGSLALITGLTFAIF	RRRKVIDFIK
356	Q9D9J7	MGPHFTLLLAALANC...FNSDYSGDKSEATEN	2	320	342	QNPEKKMKTR	LLILLTLGFVVLVASIIISVLHF	RKVSAKLKNA
357	Q6UXV1	MPLALTLLLLSGLGA...VSACTYRQNRKLLLQ	2	187	209	QMDSKYPRNQ	ALLGILISVSLAVFVFVVIVVSA	CTYRQNRKLL
358	Q5VZ72	MGDLWLFLLLPLSAF...GKIDEKEEKDFRLRK	2	178	200	RKAENREIAL	FLILLATAVILGSAVLLFHFCIF	HRRKMKAIRR
359	P57087	MARRSRHRLLLLLLR...TMSENDFKHTKSFII	2	239	261	RMQVDDLNIS	GIIAAVVVVALVISVCGLGVCYA	QRKGYFSKET
360	Q80UL9	MLCLLKLIVIPVILA...SPKASSLVRSSVRSK	2	280	302	KGQQGILNGN	QLVIIVGIVCATFLLLPVLILIV	KKAKWNKSSV
361	O76095	MLAGAGRPGLPQGRH...DRKALEKVRKQIESI	2	109	126	ALMEQRLFWK	FEGAVVCVALIFACLVII	RQRQLDRKAL
362	Q5VV43	MAPPTGVLSSLLLLV...SIRNGASFSYCSKDR	2	956	978	WDGESNCEWS	IFYVTVLAFTLIVLTGGFTWLCI	CCCKRQKRTK
363	Q8IYS2	MWLQQRLKGLPGLLS...PGAKPLFRSKEDPSV	2	592	614	HMAQQDPGLP	FLFWFSVASLITLFHLFLFKLIY	NEYCGPGAKP
364	Q9Y6H6	METTNGTETWYESLH...SDPYHVYIKNRVSMI	2	57	79	RASLPGRDDN	SYMYILFVMFLFAVTVGSLILGY	TRSRKVDKRS
365	Q9QZ26	MNCSESQRLQTLLNR...AAGALPALAQGAERV	2	59	81	REATSAKGND	AYLYILLIMIFYACLAGGLILAY	TRSRKLVEAK
366	Q99706	MSMSPTVIILACLGF...SQTQLASSNVPAAGI	2	243	265	FKTGIARHLH	AVIRYSVAIILFTILPFFLLHRW	CSKKKDAAVM
367	P83555	MLLWFLSLVCSGFFL...SEFSADTIVYMEIMK	2	337	359	DTKTNNYKNL	HILTGLLVTMVLVVIIIFYSCYF	SKQNKSQKQA
368	Q96J84	MLSLLVWILTLSDTF...SDYGQRFQQRMQTHV	2	497	519	LEEREVLPVG	IIAGATIGASILLIFFFIALVFF	LYRRRKGSRK
369	Q6UWL6	MLRMRVPALLVLLFC...AAFPTPSHPRLQTHV	2	511	533	GRRDLLPTVR	IVAGVAAATTTLLMVITGVALCC	WRHSKASASF
370	Q8IZU9	MKPFQLDLLFVCFFL...SDPSRPLQRRMQTHV	2	536	558	GLEAESVPMA	VIIGVAVGAGVAFLVLMATIVAF	CCARSQRNLK
371	P10721	MRGARGAWDFLCVLL...STASSSQPLLVHDDV	2	521	543	NNKEQIHPHT	LFTPLLIGFVIVAGMMCIIVMIL	TYKYLQKPMY
372	P05532	MRGARGAWDLLCVLL...SSASSTQPLLVHEDA	2	524	546	NNKEQIQAHT	LFTPLLIGFVVAAGAMGIIVMVL	TYKYLQKPMY
373	Q96MU8	MAPPAARLALLSAAA...KGQSQQDDRNPLVSD	2	391	413	MGAGSHRVEG	WTVYGLATLLILTVTAIVAKILL	HVTFKSHRVP
374	A6NMS7	MSSAQCPALVCVMSR...DSEAPTEEEESEALP	2	1582	1604	EVPGYGYTDK	LILALIVTGILTILIILFCLIVI	CCHRRSLQED
375	Q8BG84	MSLHPVILLVLVLCL...TDMAESSTYAAIIRH	2	143	165	SDTSWLKTYS	IYIFTVVSVIFLLCLSALLFCFL	RHRQKKQGLP
376	P13473	MVCFRLFPVPGSGLV...YFIGLKHHHAGYEQF	2	378	400	CSADDDNFLV	PIAVGAALAGVLILVLLAYFIGL	KHHHAGYEQF
377	Q9UQV4	MPRQLSAAAALFASL...YKIRLRCQSSGYQRI	2	380	402	FGNVDECSSD	YTIVLPVIGAIVVGLCLMGMGVY	KIRLRCQSSG
378	Q9UJQ1	MDLQGRGVPSIDRLR...QVQIPRDRSQYKHMG	2	236	258	PVDEREQLEE	TLPLILGLILGLVIMVTLAIYHV	HHKMTANQVQ
379	Q6UX15	MRPGTALQAVLLAVL...RSKESGWVENEIYGY	2	236	258	SREAALNLAY	ILIPSIPLLLLLVVTTVVCWVWI	CRKRKREQPD
380	Q86UK5	MDPSGSRGRPTWVLA...NFLNAKKAMRALGMD	2	299	321	VTVLPHHGLH	AAGFFIAFLLSLVLTWAALFLMV	RYQCLKGNML
381	P48357	MICQKFCVVLLHWEF...QTHKIMENKMCDLTV	2	840	862	QDDIEKHQSD	AGLYVIVPVIISSSILLLGTLLI	SHQRMKKLFW
382	P19256	MVAGSDAGRALGVLS...GILKCDRKPDRTNSN	2	216	238	IPSSGHSRHR	YALIPIPLAVITTCIVLYMNGIL	KCDRKPDRTN
383	P42702	MMDIYVCLKRPSWMV...GGWSFTNFFQNKPND	2	835	857	MYVVTKENSV	GLIIAILIPVAVAVIVGVVTSIL	CYRKREWIKE
384	Q96FE5	MQVSKRMLAGGVRSM...ISSADAPRKFNMKMI	2	560	582	FPFDIKTLII	ATTMGFISFLGVVLFCLVLLFLW	SRGKGNTKHN
385	Q6UY18	MDAATAPKQAWPPWP...GDKNSGGNRVTAKLF	2	535	557	FFLDSRGVAM	VLAVGFLPFLTSVTLCFGLIALW	SKGKGRVKHH
386	O75022	MTPALTALLCLGLSL...EPPAEPSIYATLAIH	2	442	464	PPSTPGLGRY	LEVLIGVSVAFVLLLFLLLFLLL	RRQRHSKHRT
387	Q8VCD3	MLEIRGLSPSLCLLS...IGVLRRQPISPSMQA	2	439	461	SGWLLGSSTC	LHTSIFLFFLLLQTVGFFCYVNF	SRQELDKRLQ
388	Q9H0V9	MAATLGPLGSWQQWR...ILYNKWQEQSRKRFY	2	314	336	APLPPLSGLA	LFLIVFFSLVFSVFAIVIGIILY	NKWQEQSRKR
389	Q12907	MAAEGWIWRWGWGRR...AVVFQKRQERNKRFY	2	323	345	FRSGPLTGWR	VFLLLLCALLGIVVCAVVGAVVF	QKRQERNKRF
390	A0A1B0GTW7	MLLLLLLLLLLPPLV...ELHSTRVPVRGIREV	2	734	756	TSDHNPSMTH	LRLSMGLCLMLLILVGVMGTTAY	QKRATLPVRP
391	Q86YD5	MWLLGPLCLLLSSAA...AEPRDSEPSQGTEEV	2	172	194	SENQLVYYPS	ITYAIIGSSVIFVLVVALLALVL	HHQRKRNNLM
392	Q8TF66	MPLKHYLLLLVGCQA...RSQAVLMQMKAPNEC	2	539	561	VWGMTQAQSG	LAIAAIVIGIVALACSLAACVGC	CCCKKRSQAV
393	Q9H756	MKVTGITILFWPLSM...IEDKYIDIHELCEEN	2	269	291	RNSEHEPLGK	SWAFLVGVVVTVLTTSLLIFIAI	KCPIWYNILL
394	Q8N386	MGGTLAWTLLLPLLL...GQAPMDEEEYVIPGH	2	166	188	SCAPGLASAT	IGAVVVSGCLLLGLAIAGPVLAW	RLWRCRVARS
395	Q2I0M4	MRGPSWSRPRPLLLL...ASPADPGSPAAAAQA	2	265	287	QPLALRDLAV	VYTLGPASFLVSLASCLALGSGL	TACRARRRRL
396	Q14392	MRPQILLLLALLTLG...CCCVRRQKFNQQYKA	2	629	651	EKGGLKNINL	IIILTFILVSAILLTTLAACCCV	RRQKFNQQYK
397	Q86YC3	MELLPLWLCLGFHFL...LLQVIKSRCHWSSVY	2	652	674	KWERLDLGLL	YLVLILPSCLTLLVACTVIVLTF	KKPLLQVIKS
398	Q5VT99	MRPRAPACAAAALGL...APNKDAEDEDEDKDD	2	251	273	FSLSLTDLCI	IIFSGVAVSIAAIISSFFLATVV	QCLQRCAPNK
399	Q9BTN0	MAILPLLLCLLPLAP...LDCEPWGPGHEPVGP	2	537	559	CGAPHAPFLG	GTMIIALGGVIVASVLVFIFVLL	MRYKVHGGQP
400	Q96JA1	MARPVRGGLGAPRRS...LPGKQRVPLLLAPKS	2	793	815	AAGCRKDGTT	VGIFTIAVVSSIVLTSLVWVCII	YQTRKKSEEY
401	Q9P2V4	MRVALGMLWLLALAW...AFGVKGGRRINEYFC	2	530	552	DAENTQQLIN	VVVISVAIVIALPLTLLVCCSAL	QKRCRKCFNK
402	A6NDA9	MASVFHYFLLVLVFL...DTEGDKEKGGTEDNS	2	463	485	DAGGLEAREH	LLHVTVVLCVVLLAVPVGAYAWA	AQGPCSCSKW
403	Q3SXY7	MHLFACLCIVLSFLE...QVTFKSEGSRPEYYC	2	581	603	TERVEGDDSQ	WSLLLVVTSTACVVILPLICFLL	YKVCKLQCKS
404	Q8ND94	MLGSPCLLWLLAVTF...WGCPRRAAARAAGAL	2	198	220	VPPNPRTLVH	AAVGVGTALALLSCAALVWHFCL	RDRWGCPRRA
405	Q86VZ4	MASVAQESAGSQRRL...ITSEESDYLINGMYL	2	451	473	GGEHPAPETG	AVLPLALGLAITALLLLMVACRL	RLVKQKLKKA
406	Q9Y561	MACRWSTKESPRWRS...TLKNETSDDEALLLC	2	13	32	CRWSTKESPR	WRSALLLLFLAGVYGNGALA	EHSENVHISG
407	O75096	MRRQWGALLLGALLC...TGWKHERKLSSESQV	2	1724	1746	VPAAPGEGLH	ISYAIGGLLSILLILVVIAALML	YRHKKSKFTD
408	Q8WUT4	MRQTLPLLLLTVLRP...NPAFDDYPLGLQTVS	2	683	705	AFTTKPSFAL	LLSGLCAASGLLLASTVVLSACL	CRRGQTLGLQ
409	Q86UE6	MDFLLLGLCLYWLLR...GSCTCHQQPARECEV	2	428	450	HAENAVQIHK	VVTGTMALIFSFLIVVLVLYVSW	KCFPASLRQL
410	Q9HBL6	MKGELLLFSSVIVLL...PGKVEEKERFDSSPA	2	286	308	KPRPANLRHA	IATVIITGVVCGIVCLMMLAAAI	YGCTYAAITA
411	Q5SQ64	MAVLFLLLFLCGTPQ...NIHLARLGPPAHKPR	2	235	257	CAPSTGWDMP	WILMLLLTMGQGVVILALSIVLW	RQRVRGAPGR
412	O60449	MRTGWATPRRPAGLL...QGVNEDEIMLPSFHD	2	1669	1691	CKVPLGPDYT	AIAIIVATLSILVLMGGLIWFLF	QRHRLHLAGF
413	Q9HBG7	MVAPKSHTDDWAPGP...NDLEIPESPTYENFT	2	455	476	ICSGPERNTK	LWIGLFLMVCLLCVGIFSWCIW	KRKGRCSVPA
414	P14151	MIFPWKCQSTQRDLW...LKKGKKSKRSMNDPY	2	333	355	FSMIKEGDYN	PLFIPVAVMVTAFSGLAFIIWLA	RRLKKGKKSK
415	P16581	MIASQFLSALTLVLL...SLESDGSYQKPSYIL	2	556	578	TCEAPTESNI	PLVAGLSAAGLSLLTLAPFLLWL	RKCLRKAKKF
416	P16109	MANCQIAILYQRFQR...GTYGVFTNAAFDPSP	2	773	795	AGPLTIQEAL	TYFGGAVASTIGLIMGGTLLALL	RKRFRQKDDG
417	Q9Y5Y7	MARCFSLVLLLTSIW...KSPSKTTVRCLEAEV	2	236	258	FKNEAAGFGG	VPTALLVLALLFFGAAAGLGFCY	VKRYVKAFPF
418	P20916	MIFLTALPLFWIMIS...TLTEELAEYAEIRVK	2	511	533	LPFQGAHRLM	WAKIGPVGAVVAFAILIAIVCYI	TQTRRKKNVT
419	Q5VYJ5	MLFFLDRMLAFPMNE...GTTSGSLETLSHHLK	2	2075	2097	TDFTYAQNNT	WTLLGIGLAFLMTHITVAVLCFL	ANRKVPIRKT
420	Q9H8J5	MFFGGEGSLTYTLVI...YSRLDYLINGIYVDI	2	386	408	QYGLPFEKWL	LIGSLLFGVLFLVIGLVLLGRIL	SESLRRKRYS
421	A6NHS7	MHVAEVAVNVILLLS...SLQIKNRNHMKENSS	2	286	308	DEVSVTSKTW	LVSVALCTSVIFLGCCIVILASG	CCGKQQGQYK
422	Q3UU94	MRAVELLLLLGLASM...RSASGCRRNTLKENS	2	284	306	EPWDGAPASA	GVWLACVTLGAAVISLCCRVVLG	TSRCCGKRQG
423	Q14703	MKLVNIWLLLLVVLL...PQLMQQVHPPKTPSV	2	999	1021	IMPGRYNQEV	GQTIPVFAFLGAMVVLAFFVVQI	NKAKSRPKRR
424	P15529	MEPPGRRECPFPSWR...YLTDETHREVKFTSL	2	344	366	PEEGILDSLD	VWVIAVIVIAIVVGVAVICVVPY	RYLQRRKKKG
425	Q96KG7	MVISLNSCLSFICLL...EDSGGSSSNSSSSSE	2	856	878	STALPADSYQ	IGAIAGIIILVLVVLFLLALFII	YRHKQKGKES
426	A6BM72	MVLSLTGLIAFSFLQ...VRQSPANGPSQDKQS	2	849	871	SPALGAERHS	VGAVTGIMLLLFLIVVLLGLFAW	HRRRQKEKGR
427	Q7Z7M0	MALGKVLAMALVLAL...RKGLLSQDNLTSMSL	2	2648	2670	FFRQDQAHID	LFVFFSVFFSCFFLFLSLCVLLW	KAKQALDQRQ
428	Q9H1U4	MNGGAERAMRSLPSL...NGQLTLTTPIHNYKA	2	515	537	LADVSWTQFN	IIILTVIIIVVVLLMGFVGAVYM	YREYQNRKLN
429	Q16820	MDLWNLSWFLFLDAL...SSNRPNLTPQNQHAF	2	654	676	EKRGSTRDTI	VIAVSSTVAVFALMLIITLVSVY	CTRKKYRERM
430	Q9H9K5	MGSLSNYALLQLTLT...AMKGLTTHQYDTSLL	2	490	512	FAKVGDWFRS	WGYVLLIVLFCLFIFVLIYVRVF	RKSRRSLNSQ
431	O75121	MDRLKSHLTVCFLPS...VTHDKNTCIIYESHV	2	150	172	LRVIFTSGDM	GVYYMVVCLVAFTIVMVLNITRL	CMMSSHLKKT
432	Q29983	MGLGPVFLLLAGIFP...PLMSDLGSTGSTEGA	2	306	328	PSGKVLVLQS	HWQTFHVSAVAAAAIFVIIIFYV	RCCKKKTSAA
433	P51512	MILLTFSTGRRLDFV...PRHILYCKRSMQEWV	2	565	587	LDNTASTVKA	IAIVIPCILALCLLVLVYTVFQF	KRKGTPRHIL
434	Q8TD46	MLCPWRTANLGLLLI...SEALQSEVDTDLHTL	2	244	266	VPGAKKSAKL	YIPYIILTIIILTIVGFIWLLKV	NGCRKYKLNK
435	Q6Q8B3	MSAPRLLISIIIMVS...GFVFFQRINHVRKVL	2	239	261	RTSGSPALSL	LIILYVKLSLFVVILVTTGFVFF	QRINHVRKVL
436	Q2M385	MNNFRATILFWAAAA...ATGDTTYQEQGQSPA	2	656	678	HGDGGGLSGG	AAAGVTVGVTTILAVVITLAIYG	TRKFKKKAYQ
437	P20645	MFPFYSCWRTGLLLL...LGEESEERDDHLLPM	2	188	210	ACSPEISHLS	VGSILLVTFASLVAVYVVGGFLY	QRLVVGAKGM
438	P11717	MGAAAGRSPHLGPAP...LVSFHDDSDEDLLHI	2	2305	2327	MHKGLSERSQ	AVGAVLSLLLVALTCCLLALLLY	KKERRETVIS
439	Q3TEW6	MAEAVGAVALIAAPA...INKSESVVYADIRKD	2	162	191	LHVVEIDNLL	VFLVWVVVGTVTAVVLGLTLLISLVLVVLY	RRKHSKRDYT
440	O60487	MYGKSSTRAVLLLLG...LNQEKKVSVYLEDTD	2	153	175	VHTVRFSEIH	FLALAIGSACALMIIIVIVVVLF	QHYRKKRWAE
441	Q6UWV2	MQQRGAAGSRGCALF...VRCAECLDSDYEETY	2	159	181	ERGFGTMLSS	VALLSILVFVPSAVVVALLLVRM	GRKAAGLKKR
442	Q61830	MRLLLLLAFISVIPV...KDLMGNIEQNEHAII	2	1388	1410	MDPQPKGSSK	AAGVVTVVLLIVIGAGVAAYFFY	KKRHALHIPQ
443	Q13505	MLLGGPPRSPRSGTS...PGTRTLGMAEEDEEE	2	421	443	EEEPYRRRNQ	ILSVLAGLAAMVGYALLSGIVSI	QRATPARAPG
444	Q9UKN1	MLVIWILTLALRLCA...TELHIQRPEMVASTV	2	5381	5403	EFNIAKSLVY	GIVGAVMAVLLLALIILIILFSL	SQRKRHREQY
445	Q9H3R2	MKAIIHLTLLALLSV...QNPYSRHSSMPRPDY	2	421	443	SGLDCKDKFQ	LILTIVGTIAGIVILSMIIALIV	TARSNNKTKH
446	Q8C6Z1	MLTLAKIALISSLFI...DGIPMDAIPPLRPSI	2	235	257	DTPKENKNTG	IVFGAILGAILGASLLSLVGYLL	CGQRKTDSFS
447	Q8WXI7	MLKPSGLPGSSSPTR...CPGYYQSHLDLEDLQ	2	14453	14475	PLTGNSDLPF	WAVILIGLAGLLGVITCLICGVL	VTTRRRKKEG
448	Q5SSG8	MKMQKGNVLLMFGLL...VSSIAMEMSGRNSGP	2	480	502	KPGGSLVPWE	IFLITLVSVVAAVGLFAGLFFCV	RNSLSLRNTF
449	Q04900	MSRLSRSLLWAATCL...LYKFCKSKERNYHTL	2	164	186	QPVRKSTFDA	ASFIGGIVLVLGVQAVIFFLYKF	CKSKERNYHT
450	Q9ULC0	MELLQVTILFLLPSI...SHESGEHSAQGKTKN	2	191	213	TSATSRSYSS	IILPVVIALIVITLSVFVLVGLY	RMCWKADPGT
451	Q3MIW9	MAQPVHSLCSAFGLQ...MEQQNLGMGQIPSPR	2	447	469	QMGENDSFPA	WAIVIVVLVAVILLLVFLGLIFL	VSYMMRTRRT
452	Q9BRK3	MALPSRILLWKLVLL...KYIDLDKGFRKENCK	2	341	363	VPESRAHFFQ	QLGYVLATLLLFILLLVTVLLAA	RRRRGGYEYS
453	P25189	MAPGAPSSSPSPILA...EKKAKGLGESRKDKK	2	157	179	FEKVPTRYGV	VLGAVIGGVLGVVLLLLLLFYVV	RYCWLRRQAA
454	Q9UK23	MATSTGRWLLLRLAL...AEKEQPGGAHNPFKD	2	450	472	GELSFFTRTA	WLALTLALAFLLLISTAANLSLL	LSRAERNRRL
455	P13591	MLQTKDLIWTLFFLG...VPNDATQTKENESKA	2	724	746	SPTSGLSTGA	IVGILIVIFVLLLVVVDITCYFL	NKCGLFMCIA
456	O35136	MSLLLSFYLLGLLVR...VSNDIIQSKEDDIKA	2	696	718	PKPNIIKDTL	FNGLGLGAIIGLGVAALLLILVV	TDVSCFFIRQ
457	Q5T1S8	MTTATPLGDTTFFSL...ATVTFSPVDVQVETR	2	29	51	TRGEDFLYKS	SGAIVAAVVVVVIIIFTVVLILL	KMYNRKMRTR
458	O76036	MSSTLPALLCVGLCL...ASTWEGRRRLNTQTL	2	256	274	HALWDHTAQN	LLRMGLAFLVLVALVWFLV	EDWLSRKRTR
459	O95944	MAWRALHPLLLLLLL...VARTKISDDDDEHTL	2	193	215	LRPGPAAPIA	LVPVFCGLLVAKSLVLSALLVWW	GDIWWKTMME
460	Q96NY8	MPLSLGAEMWGPEAW...PTGNGIYINGRGHLV	2	350	372	GKQVDLVSAS	VVVVGVIAALLFCLLVVVVVLMS	RYHRRKAQQM
461	Q8TDF5	MIHGRSVLHIVASLI...GSLSKHESEYNTTRV	2	343	365	SLLDQLTNTS	GTVIGVTSCIVIILIIISVIVQI	KQPRKKYVQR
462	Q8NET5	MENQPVRWRALPGLP...RFEDDGELNLVYENL	2	164	186	YREPPQSPQK	LLLFGFTGLLSVLSVVGTALLLW	NKKRMRGPGK
463	Q92542	MATAGGGSGADPGSR...DVLFIAPREPGAVSY	2	670	692	IFLIASKELE	LITLTVGFGILIFSLIVTYCINA	KADVLFIAPR
464	O60500	MALGTTLRASLLLLG...LEPDSLPFELRGHLV	2	1064	1086	PSGPSGLPLL	PVLFALGGLLLLSNASCVGGVLW	QRRLRRLAEG
465	Q68D85	MTWRAAASTCAALLI...PVLSSQPPTLLLPLQ	2	262	284	LSETEKTDNF	SIHWWPISFIGVGLVLLIVLIPW	KKICNKSSSA
466	O35181	MSEGAAGASPPGAAS...FVLRNEIQRDSVLTK	2	363	385	MESEDVYQRQ	VLSISCIIFGIVIVGMFCAAFYF	KSKKQAKQIQ
467	Q8WWG1	MPTDHEEPCGPSHKS...VETSSTSAHHSHEQH	2	61	83	PGSSIQTKSN	LFEAFVALAVLVTLIIGAFYFLC	RKGHFQRASS
468	O14786	MERGLPLLCAVLALV...LKKDKLNTQSTYSEA	2	857	879	PGNVLKTLDP	ILITIIAMSALGVLLGAVCGVVL	YCACWHNGMS
469	Q96PE5	MSFSLNFTLPANTTS...RRRGLWWLVPRLSLE	2	31	53	GKETDCGPSL	GLAAGIPLLVATALLVALLFTLI	HRRRSSIEAM
470	Q99650	MALFAVFQTTFFLTL...SLSSITLLDPGEHYC	2	739	761	TKVTTPDEHS	SMLIHILLPMVFCVLLIMVMCYL	KSQWIKETCY
471	Q86WC4	MEPGPTAAQRRCSLP...LKSSTSFANIQENSN	2	283	305	FNCSVPCSDT	VPVIAVSVFILFLPVVFYLSSFL	HSEQKKRKLI
472	Q96FE7	MLLAWVQAFLVSNML...EGTTPLMGQAGTPGA	2	169	191	NSKEKKDLGT	LGYVLGITMMVIIIAIGAGIILG	YSYKRGKDLK
473	Q8NBR0	MAPPPPSPQLLLLAA...LPPTPDSGPEGESSE	2	310	329	ARGPTPRTEE	AAWAAMALTFLLVLLTLATL	CTRLHRNFRR
474	Q6UWI2	MVYKTLFALCILTAG...YGSWGNYNNPLYDDS	2	258	280	QEVEHALSSG	SIAAITVTVIAVVLLVFGVAAYL	KIRHSSYGRL
475	Q923D3	MVCKVLIALCIFTAG...YGSWGNYNNPLYDDS	2	244	266	QEVENALSSG	SIAAITVTVIAVVLLVFGGAAYL	KIRHSSYGRL
476	Q9P2E7	MIVLLLFALLWMVEG...RAPYKPPYLTRKRIC	2	716	738	GGGETSLDLT	LILIIALGSVSFIFLLAMIVLAV	RCQKEKKLNI
477	Q96QU1	MFRQFYLWTCLASGI...VEGTEKQSHSQSTSL	2	1375	1397	KRGESLGYTE	GALLALAFIIILCCIPAILVVLV	SYRQFKVRQA
478	Q9HCL0	MHQMNAKMHFRFVFA...LVAEINKLLQDVRQS	2	698	720	MTSVSQASLD	VSMIIIISLGAICAVLLVIMVLF	ATRCNREKKD
479	Q8TAB3	MESLLLPVLLLLAIL...NKESPGVKRLKDIVL	2	679	701	QESMGSVNLS	LIFIIALGSIAGILFVTMIFVAI	KCKRDNKEIR
480	Q8N6Y1	MRGRGNARSSQALGV...DLHMRERKPMDISNI	2	889	911	RKVESVSCMP	TLVALSVISLGSITLVTGMGIYI	CLRKGEKHPR
481	Q9Y5F3	MAGTRRKSLQNRQVG...SQRLEGHDQVSDDYM	2	690	712	HSRKVNPSTK	YLVISLVILSFLFLLSVIVIFII	HVYQKIKYRE
482	Q9H158	MVGCGVAVLCLWVSC...EKKEKGNSTTDNSDQ	2	682	704	EPGGQLSAQN	LYLVIALACISFLFLGCLLFFVC	TKLHQSPGCC
483	Q9Y5F7	MLRKVRSWTEIWRWA...GGNGNKKKSGKKEKK	2	690	712	SAPREGESRL	TLYLAVSLVAICFVSFGSFVALL	SKCLRGAACG
484	O60245	MLRMRTAGWARGWCL...YSKQMRLHPYITVFG	2	878	900	DPSYEISKQR	LSIVIGVVAGIMTVILIILIVVM	ARYCRSKNKN
485	Q7TSK3	MSPAKRWGSPCLFPL...GSRYVSPKKGINENV	2	748	770	SGPSLQWDTP	LIVIIVLAGSCTLLLAAIIAIAT	TCNRRKKEVR
486	Q9HC56	MDLRDFYLLAALIAC...KQAGGATESPKEHQL	2	814	836	SQPYQNEDYL	TIMIAIIAGAMVVIVVIFVTVLV	RCRHASRFKA
487	Q92824	MGWGSRCCCPGRLDL...IDELEYDDESYSYYQ	2	1745	1764	RPATEHFKTA	LFITSSMMLVLLLGAAVVVW	KKSRGRVQPA
488	Q16549	MPKGRQKVPHLDAPL...HQHLDVPHGKEEQIC	2	13	35	KGRQKVPHLD	APLGLPTCLWLELAGLFLLVPWV	MGLAGTGGPD
489	Q9EP73	MRIFAGIIFTACCHL...DTSSKNRNDTQFEET	2	238	260	LPATHPPQNR	THWVLLGSILLFLIVVSTVLLFL	RKQVRMLDVE
490	Q9BQ51	MIFLLLMLSLELQLH...KRPVTTTKREVNSAI	2	221	243	SQMEPRTHPT	WLLHIFIPFCIIAFIFIATVIAL	RKQLCQKLYS
491	Q15116	MQIPQAPWPVVWAVL...AQPLRPEDGHCSWPL	2	168	190	PSPRPAGQFQ	TLVVGVVGGLLGSLVLLVWVLAV	ICSRAARGTI
492	Q9NZ53	MGRLLRAARLPPLLS...RDPEDSDVFEEDTHL	2	500	522	RASQVRSDYG	TLFVVLVVIGAICIIIIALGLLY	NCWQRRLPKL
493	P16284	MQPRWAQGATMWLGV...VESRYSRTEGSLDGT	2	603	625	RVILAPWKKG	LIAVVIIGVIIALLIIAAKCYFL	RKAKAKQMPV
494	P07202	MRALAVLSVTLVMAC...AGMEGRDTHRLPRAL	2	849	871	VDSGRLPRVT	WISMSLAALLIGGFAGLTSTVIC	RWTRTGTKST
495	Q8IYJ0	MESRMWPALLLSHLL...GAPAFQLNRIPLVNL	2	181	203	GRGEGVDPQL	YVTITISIIIVLVATGIIFKFCW	DRSQKRRRPS
496	P01833	MLLFVLTCLLAVFPA...SSTVAAEAQDGPQEA	2	639	661	SSEEQGGSSR	ALVSTLVPLGLVLAVGAVAVGVA	RARHRKNVDR
497	Q969N2	MAAAMPLALLVLLLL...RLANLIRRARGVPPL	2	522	544	PLLVNLPTPD	FSMPYNVICLTCTVVAVCYGSFY	NLLTRTFHIE
498	Q9UKJ1	MGRPLLLPLLPLLLP...LKSPQNETLYSVLKA	2	196	218	RSDSWHISLE	TAVGVAVAVTVLGIMILGLICLL	RWRRRKGQQR
499	Q13018	MLLSPSLLLLLLLGA...LEENILISDLEKSDQ	2	1398	1420	ALPEKGPSHS	IIPLAVVLTLIVIVAICTLSFCI	YKHNGGFFRR
500	Q3TTY0	MELYPGVSPVGLLLL...VTQDAVSEKRLKAGN	2	1420	1442	LPDKAEEPSN	ALYWAVPVAAIGGLAVGILGVML	WRTVKPVQQE
501	Q9Z239	MASPGHILALCVCLL...GTFRSSIRRLSSRRR	2	35	57	EPDPFTYDYH	TLRIGGLTIAGILFILGILIILS	KRCRCKFNQQ
502	O75051	MEQRRPWPRALEVDS...AYKVEQLINAMSIES	2	1238	1260	VISDSLLTLP	AIVSIAAGGSLLLIIVIIVLIAY	KRKSRENDLT
503	Q9QY40	MLTDFLQAPVMAPWS...LQQVAALVEYKVTDL	2	1244	1266	ESMMSTFPVE	AQLGLGMGAAVLIAAVLLLTLMY	RHKSKKALRD
504	Q9QZC2	MEVSRRKTPPRPPYP...HVKVLFDEKKKCKWM	2	950	972	LYVEQESVPS	TWYFLIALPILLAIVIVVAVVVT	RYKSKELSRK
505	Q8TEM1	MAARGRGLLLLTLSV...ASPPSGLWSPAYASH	2	1809	1831	LFQHFLDSYQ	VMFFTLFALLAGTAVMIIAYHTV	CTPRDLAVPA
506	O00592	MRCALALSALLLLLS...NLTKDDLDEEEDTHL	2	461	483	PEEAEDRFSM	PLIITIVCMASFLLLVAALYGCC	HQRLSQRKDQ
507	Q8N131	MGLGARGAWAALLLG...RGIRYRTIDEHDAII	2	169	191	KKGSKFDTGS	FVGGIVLTLGVLSILYIGCKMYY	SRRGIRYRTI
508	P16471	MKENVASATVFTLLL...GLDYLDPACFTHSFH	2	236	258	IPSDFTMNDT	TVWISVAVLSAVICLIIVWAVAL	KGYSMVTCIF
509	P0DTF9	MCWLRAWGQILLPVF...ETVPIHDRSATVYDE	2	98	120	SIYWLNCKVD	MFGIMMLLLIAVLITGFVWYCCA	YHFYLQDLNR
510	P18433	MDSWFILVLLGSGLI...VQEYIDAFSDYANFK	2	152	174	DSKDRRDETP	IIAVMVALSSLLVIVFIIIVLYM	LRFKKYKQAG
511	B2RU80	MLRHGALTALWITLS...NVNPEYHRDAIYSRH	2	1620	1642	ITTESEPLFG	VIEGVSAGLFLIGMLVALVAFFI	CRQKASHSRE
512	P08575	MTMYLWLKLLAFGFA...HSVNGPASPALNQGS	2	580	602	HSTSYNSKAL	IAFLAFLIIVTSIALLVVLYKIY	DLHKKRSCNL
513	P23469	MEPLCPLLLVGFSLP...VQDFIDIFSDYANFK	2	47	69	GPPDPGASQP	LLAWLLLPLLLLLLVLLLAAYFF	RFRKQRKAVV
514	P23470	MRRLLEPCWWILFLK...IADESDPAESMESLV	2	737	759	ISRPAPGRME	WIIPLIVVSALTFVCLILLIAVL	VYWRGCNKIK
515	Q12913	MKPAAREARLPPRSP...LAPVTTFGKTNGYIA	2	974	996	VSLPQDPGVI	CGAVFGCIFGALVIVTVGGFIFW	RKKRKDAKNN
516	Q16849	MRRPRRPGGLGGSGG...AVAEEVNAILKALPQ	2	577	599	TAHSTSPMRS	VLLTLVALAGVAGLLVALAVALC	VRQHARQQDK
517	E9Q612	MGHLPRGTLGGRRLL...QFCISDVIYENVSKS	2	831	853	TMVTEVNPNV	VVISVLAILSTLLIGLLLVTLVI	LRKKHLQMAR
518	Q9UMZ3	MKKVPIKPEQPEKLR...AMEGDVELEWEETTM	2	1948	1970	GEGLSERTVE	IILSVTLCILSIILLGTAIFAFA	RIRQKQKEGG
519	Q15256	MRRAVCFPALCLLLN...ALCLYESRLSAETVQ	2	227	249	HEADKIWSKE	GFYAVVIFLSIFVIIVTCLMILY	RLKERFQLSL
520	Q99M80	MGSLGGLALCLLRLL...YKFVYEVALEYLSSF	2	772	791	KQVDNTVKMA	GVIAGLLMFIIILLGVMLTI	KRRKLAKKQK
521	Q92729	MARAQALVLALTFQL...CYDVALEYLEGLESR	2	747	769	EVSQRSEEMG	LILGICAGGLAVLILLLGAIIVI	IRKGRDHYAY
522	P70289	MRPLILLAALLWLQD...CLNSALRNRLPRARK	2	1078	1100	QASISLVAMP	LTVMMGTVVGCIIIVCAVLCLLC	RRGLKGPRSE
523	P15151	MARAMAAAWPLLLVA...RENSSSQDPQTEGTR	2	345	367	SEHSGISRNA	IIFLVLGILVFLILLGIGIYFYW	SKCSREVLWH
524	Q9NXS2	MRSGGRGRPRLRLGE...LCRILAVFLAEYLGL	2	33	55	LPPKRRLLPR	VRLLPLLLALAVGSAFYTIWSGW	HRRTEELPLG
525	Q8TD07	MRRISLTSSPVRLLL...QNGEWQAGLWPLRTS	2	226	248	IHWSSSSLPD	RWIILGAFILLVLMGIVLICVWW	QNGEWQAGLW
526	O75787	MAVFVVLLALVAGVL...DSIIYRMTNQKIRMD	2	309	331	YNFEYSVVFN	MVLWIMIALALAVIITSYNIWNM	DPGYDSIIYR
527	P07949	MAKATSGAAGLRLLL...MLSPSAAKLMDTFDS	2	13	32	KATSGAAGLR	LLLLLLLPLLGKVALGLYFS	RDAYWEKLYV
528	Q68DV7	MSGGHQLQLAALWPW...PGSEEELEELCEQAV	2	199	218	KEPPAWPDYD	VWILMTVVGTIFVIILASVL	RIRCRPRHSR
529	Q04912	MELLPPLPQSFLLLL...NVRRPRPLSEPPRPT	2	960	982	PDGVPQSTLL	GILLPLLLLVAALATALVFSYWW	RRKQLVLPPN
530	Q01974	MARGSALPRRPLLCI...CDTLQVDEAQVQLEA	2	403	425	SCSPRDSSKM	GILYILVPSIAIPLVIACLFFLV	CMCRNKQKAS
531	P08922	MKNIYCLIPKLVNFA...NYACLTHSGYGDGSD	2	1860	1882	LVGDDFWIPE	TSFILTIIVGIFLVVTIPLTFVW	HRRLKNQKSA
532	P04843	MEAPAAGLFLLLLLG...RQELVTKIDHILDAL	2	440	459	FNKVLMLQEP	LLVVAAFYILFFTVIIYVRL	DFSITKDPAA
533	Q9HBV2	MSPRGTGCSAGLLMT...TEMPGEDDALSEWNE	2	217	239	MRRSSLPATD	AALIFVLTIGVIICVFIIFLLIF	IIINWAAVKA
534	Q96BY9	MAAACGPGAAGYCLL...TKTRTASGYGGTRRR	2	172	194	YYKWSSADSC	NMSGLITIVVLLGIAFVVYKLFL	SDGQYSPPPY
535	P21583	MKKTQTWILTCIYLQ...EISMLQEKEREFQEV	2	215	237	KNPPGDSSLH	WAAMALPALFSLIIGFAFGALYW	KKRQPSLTRA
536	Q9JL59	MLAYSVTSSGLFPRM...LIHGSPGIPYLTLPP	2	160	182	PDKPPTAVRT	EVIIIIAIATTIIITGIGVFVWY	KQFPVAPQIQ
537	Q8WVN6	MQTCPLAFPGHVSQA...ELLSPQPLFPYAADP	2	146	168	AEPQSAPDTG	FWPVPAVVTAVFILLVALVMFAW	YRCRCSQQRR
538	Q7Z5N4	MARGARPSAAGGGGG...GPGARTPLTGFSSFV	2	2008	2030	AQVEAPFYEE	WWFLLVMALSSLIVILLVVFALV	LHGQNKKYKN
539	Q9UBV2	MRVRIGLTLLLCAVL...APPQQEGPPEQQPPQ	2	739	761	MFTQLDMDQL	LGPEWDLYLMTIIALLLGTVIAY	RQRQHQDMPA
540	Q14242	MPLQLLLLLILLGPG...EDREGDDLTLHSFLP	2	321	343	APDHISVKQC	LLAILILALVATIFFVCTVVLAV	RLSRKGHMYP
541	Q9H3S1	MALPALGLDPWSLLG...SDVDADNNCLGTEVA	2	681	703	GAALAAQQSY	WPHFVTVTVLFALVLSGALIILV	ASPLRALRAR
542	Q92854	MRMCTPIRGLLMALA...VKCELKFADSDADGD	2	734	756	KTMYLKSSDN	RLLMSLFLFFFVLFLCLFFYNCY	KGYLPRQCLK
543	Q9Z123	MLARAERPRPGPRPP...RLTGAPLATCDETSI	2	665	687	QRGPANRAHT	VVGAGLVGFFLGVLAASLTLLLI	GRRQQRRRQR
544	Q9NTN9	MWGRLWPLLLSILTA...RKHTQLVEQLDESSV	2	679	701	LAPDVRLLYV	LAIAALGGLCLILASSLLYVACL	REGRRGRRRK
545	Q13591	MKGTCVIAWLFSSLG...YSNAYFTDLNNYDEY	2	971	993	KRCGEFNMFH	MIAVGLSSSILGCLLTLLVYTYC	QRYQQQSHDA
546	Q9H2E6	MRSEALLLYFTLLHF...FAPLSTSMKPNDACT	2	648	670	YLKGHDQLVP	VTLLAIAVILAFVMGAVFSGITV	YCVCDHRRKD
547	Q9H3T3	MQTPRASPPRPALLL...LLPYGGADRTAPPVP	2	602	624	GLVSVNLLVT	SSVAAFVVGAVVSGFSVGWFVGL	RERRELARRK
548	Q9WTM3	MPRAPHSMPLLLLLL...ASPPQPAPHGGHFNF	2	604	626	SPASASRSIP	IPLLLACVAAAFALGASVSGLLV	SCACRRANRR
549	Q8NFY4	MRVFLLCAYILLLMV...VPQTPSVRPLNKYTY	2	664	686	ESNQMVHMNV	LITCVFAAFVLGAFIAGVAVYCY	RDMFVRKNRK
550	Q53EL9	MRPVALLLLPSLLAL...TYETGSLSFAGDERI	2	926	948	AASSTLDAAH	IAAAIFLPLVAMVLLVGGVYFYF	SRLQGKSSLQ
551	Q16586	MAETLFWTPLLVVLL...PRVDSAQVPLILDQH	2	290	312	EAPDRDFLVD	ALVTLLVPLLVALLLTLLLAYVM	CCRREGRLKR
552	Q6UWI4	MWGARRSSVSSSWNA...PHTNSEQKMYPAVTV	2	114	136	KDGPDGSAVP	IYVPFLIVGSVFVAFIILGSLVA	ACCCRCLRPK
553	Q96DD7	MPPAGLRRAAPLTAI...APPPYMPPQPSYPGA	2	86	108	KHCLAFSPKT	IAGIASAVILFVAVVATTICCFL	CSCCYLYRRR
554	Q6ZSJ9	MALRRLLLLLLLSLE...GHHTCYTASKTEVTV	2	176	195	KYDPEKDKTN	FTVYITCGVIAFVIVAGVFA	KVSYDKAHRP
555	B8ZZ34	MARAGARGLLGGRRP...GSRYLRTNSKTEVTV	2	141	163	RDPGRERSHT	AVYAVCGVAALLVLAGIGARLGL	ERAHSPRARR
556	Q3SXP7	MTSCGQQSLNVLAVL...DAHSPPLMTFQSSSA	2	99	121	EGYMHNNYTA	LLGVWIYGFFVLMLLVLDLLYYS	AMNYDICKVY
557	Q96LC7	MLLPLLLSSLLGGSQ...MPKGTQADYAEVKFQ	2	548	570	PDKKGLISTA	FSNGAFLGIGITALLFLCLALII	MKILPKRRTQ
558	Q08ET2	MLPLLLLPLLWGGSL...TRCGGPQQSRAERPG	2	359	381	KQQGSWPLVL	TLIRGALMGAGFLLTYGLTWIYY	TRCGGPQQSR
559	O43699	MQGAQEASASEMLPL...PKVTDTEYSEIKIHK	2	346	368	VHWKPEGRAG	GVLGAVWGASITTLVFLCVCFIF	RVKTRRKKAA
560	Q9NYZ4	MLLLLLLLPLLWGTK...ACLRNHNPSSKEVRG	2	362	384	TSRPVSQVTL	AAVGGAGATALAFLSFCIIFIIV	RSCRKKSARP
561	Q5JXA9	MCSTMSAPTCLAHLP...PAGAMNTLAWSKGQE	2	289	311	PATEMSPTGL	LVVFAPVVLGLKAITLAALLLAL	ATSRRSPGQE
562	Q9Y3P8	MNQADPRLRAVCLWT...SFPDQAYANSQPAAS	2	41	63	LALGIPSITQ	AWGLWVLLGAVTLLFLISLAAHL	SQWTRGRSRS
563	Q13291	MDPKGLLSLTFVLFL...TNSITVYASVTLPES	2	238	260	CRTDPSETKP	WAVYAGLLGGVIMILIMVVILQL	RRRGKTNHYQ
564	Q9QUM4	MDPKGSLSWRILLFL...PNPTTVYASVTLPES	2	243	265	KQESSSESSP	WMQYTLVPLGVVIIFILVFTAII	MMKRQGKSNH
565	Q9UIB8	MAQHHLWILLLCLQT...QDSKPPGTSSYEIVI	2	224	246	DIAMGFRTHH	TGLLSVLAMFFLLVLILSSVFLF	RLFKRRQGRI
566	Q96DU3	MLWLFQSLLFVFCFG...SKPTFSRATALDNVV	2	226	248	DVKIQYTDTK	MILFMVSGICIVFGFIILLLLVL	RKRRDSLSLS
567	Q9ET39	MAVSRAPAPDSACQR...QPITLKVNTLINYNS	2	240	262	KGVLTNPPWN	AVWFMTTISIISAVILIFVCWSI	HVWKRRGSLP
568	Q8BHK6	MARFSTYIIFTSVLC...AKPLVPRSLSFENVI	2	224	246	DAATDLTSLR	GILYILCFSAVLILFAVLLTIFH	TTWIKKGKGC
569	Q9D3G2	MWSLWSLLLFEALLP...ACTDGVLPETENALV	2	234	256	SGKASYKDVL	LVVVPITLFLILAGLFGAWHHGL	CSGKKKDACT
570	Q96A28	MCAFPWLLLLLLLQE...RMKLRKEAKPGSSPA	2	240	259	PSTAFCLLAK	GLLIFLLLVILAMGLWVIRV	QKRHKMPRMK
571	Q96PX8	MLLWILLLETSLCFA...GAHRVYDCGSHSLSD	2	621	643	DTSRVSISVL	VPGLLLVFVTSAFTVVGMLVFIL	RNRKRSKRRD
572	Q9H156	MLSGVWFLSVLTVAG...DYLEVLEKQTAISQL	2	622	644	LHTEVPLSVL	ILGLLVVFILSVCFGAGLFVFVL	KRRKGVPSVP
573	Q3V0X1	MKPLKLFCIGLLLCP...SLEMQNMNLIKLFGG	2	83	105	FKNHLSDFFK	SSIPPAAIFALFVTTAIMRAAIV	NKRLEEPHRQ
574	Q62230	MCVLFSLLLLASVFS...ATKKNTIQEEVVAAL	2	1641	1663	LHQLQLFQRL	LWVLGFLAGFLCLLLGLVAYHTW	RKKSSTKLNE
575	Q96PQ0	MAHRGPSRASKGPGP...VLSINSREMHSYLVS	2	1078	1100	GTGAEQLGGG	GGYWAVVVLFVIGLFAAGAFILY	KFKRKRPGRT
576	Q9WU03	MAQLCELRRGRALLA...TADDKEQLVKNTCVL	2	198	220	MHPFLTPGLK	AVILVGLFLMVLILLLGTSMVCL	IRVVRRKQER
577	P43307	MRLLPRLLLLLLLVF...LPRKRAQKRSVGSDE	2	207	229	IEREDGLDGE	TIFMYMFLAGLGLLVIVGLHQLL	ESRKRKRPIQ
578	P43308	MRLLSFVVLALFAVT...YSSKRKYDTPKTKKN	2	147	169	REFDRRFSPH	FLDWAAFGVMTLPSIGIPLLLWY	SSKRKYDTPK
579	Q9NY15	MAGPRGLLPLCLLAF...LEEDFPDTQRILTVK	2	2477	2499	AVLAPEAPPV	AAGVGAVLAAGALLGLVAGALYL	RARGKPMGFG
580	Q8WWQ8	MMLQHLVIFCLGLVV...SEERQLEGNDPLRTL	2	2461	2483	APVTLTHTGL	GAGIFFAIILVTGAVALAAYSYF	RINRRTIGFQ
581	Q13586	MDVCVRLALWLLWGL...RKKFPLKIFKKPLKK	2	214	232	LLTRHNHLKD	FMLVVSIVIGVGGCWFAYI	QNRYSKEHMK
582	Q9UGT4	MKPALLPWALLLLAT...LRRRKGNTHVWGAQP	2	786	808	PKCQPGRSYA	VLLGIIFGGLAVVAAVALVYVLL	RRRKGNTHVW
583	Q5VX71	MYHGMNPSNGDGFLE...GIDIADEIPLMEEDP	2	317	339	QTWPSTHETL	LTTWKIVAFTATSVLLVLLLVIL	ARMFQTKFKA
584	O60279	MTAEGPSPPARWHRR...RQARHYHQQIEMEKV	2	576	598	GCPGLSRGPV	IATIVTVLCLLLLLAGVGMVWGY	RKCQHKSSVY
585	Q9UQF0	MALPYHIFLFTVLLP...SAAQPLLRPNSAGSS	2	455	477	MPWILPFLGP	LAAIILLLLFGPCIFNLLVNFVS	SRIEAVKLQM
586	Q24JP5	MCARMAGRTTAAPRG...PEELRNYMERIRGSS	2	851	873	QHVTELELGM	YALLGVFCVAIFIFLVNGVVFVL	RYQRKEPPDS
587	P40200	MEKKWKYCAVYYIIQ...EPNESDLPYHEMETL	2	518	540	TGIVVNKPKD	GMSWPVIVAALLFCCMILFGLGV	RKWCQYQKEI
588	B6A8C7	MIPKLLSLLCFRLCV...SRNVSPGESEAFKPE	2	234	256	TTSSNYSLGN	FVRLGLAAVIVVIMGAFLVEAWY	SRNVSPGESE
589	A0A1B0GTY4	MSNQRLPLIFSLLFI...CKLKKKSKEEGARRY	2	76	98	FANMDIFQGC	LYLIYNLLQAVFFVLFVLSVHYL	WKKWKKHQKK
590	P13726	METPAWPRVPRPETA...GVGQSWKENSPLNVS	2	252	274	MGQEKGEFRE	IFYIIGAVVFVVIILVIILAISL	HKCRKAGVGQ
591	P37173	MGRGLLRGLWPLHIV...SEEKIPEDGSLNTTK	2	167	189	NPDLLLVIFQ	VTGISLLPPLGVAISVIIIFYCY	RVNRQQKLSS
592	O43493	MRFVVALVLLNVAAA...RRPKASDYQRLDQKS	2	385	402	SGNGSAESSH	FFAYLVTAAILVAVLYIA	HHNKRKIIAF
593	Q9UPZ6	MGLQARRWASGSRGA...RLKPLTLAYDGDADM	2	1607	1629	PFGPDGRLKT	WVYGVAAGAFVLLIFIVSMIYLA	CKKPKKPQRR
594	Q9NS62	MKPMLKDFSNLLLVV...EDETTSTLSVEKLVI	2	414	436	QPQGPVKSNN	IVTVTGISLCLFIIIATVLITLW	RRFGRPAKCS
595	Q02763	MDSLASLVLCGVSLL...KFTYAGIDCSAEEAA	2	748	770	PADLGGGKML	LIAILGSAGMTCLTVLLAFLIIL	QLKRANVQRR
596	Q495A1	MRWCLLLIWAQGLRQ...SYRSLGNCSFFTETG	2	142	164	AEHGARFQIP	LLGAMAATLVVICTAVIVVVALT	RKKKALRIHS
597	Q96H15	MSKEPLILWLMIEFW...DVQHGREDEDGLFTL	2	314	336	MSMKNEMPIS	QLLMIIAPSLGFVLFALFVAFLL	RGKLMETYCS
598	Q8TB96	MAAAGRLPSSWALFS...REKRQEAHRFHFDAM	2	566	588	SAKLYLTPSN	IVLLTAIALIGVCVFILAIIGIL	HWQEKKADDR
599	Q6R5P0	MPRMERHQFCSVLLI...EQLKRRLSKAGQERD	2	719	741	FSFLATNCPH	GTEFWGFLTSFILLLLLIILPLI	SCPKWSWLHH
600	Q15399	MTSIFHFAIIFMLIL...LRAAINIKLTEQAKK	2	582	604	MSELSCNITL	LIVTIVATMLVLAVTVTSLCSYL	DLPWYLRMVC
601	Q9QUN7	MLRALWLFWILVAIT...QQEVFWVNLRTAIKS	2	588	610	ARPSVLECHQ	AALVSGVCCALLLLILLVGALCH	HFHGLWYLRM
602	O15455	MRQTLPCIYFWGGLL...RHKLQVALGSKNSVH	2	703	725	TSSCKDSAPF	ELFFMINTSILLIFIFIVLLIHF	EGWRISFYWN
603	O00206	MMSASRLAGTLIPAM...GTVGTGCNWQEATSI	2	634	656	NITCQMNKTI	IGVSVLSVLVVSVVAVLVYKFYF	HLMLLAGCIK
604	O60602	MGDHLDLLLGVVLMA...KKDNNIPLQTVATIS	2	644	666	VLKSLKFSLF	IVCTVTLTLFLMTILTVTKFRGF	CFICYKTAQR
605	Q9NYK1	MVFPMWTLKRQILIL...TDNHVAYSQVFKETV	2	843	865	CELDLTNLIL	FSLSISVSLFLMVMMTASHLYFW	DVWYIYHFCK
606	Q9NR97	MENMFLQSSMLTCIF...DSRYNNMYVDSIKQY	2	826	848	SLELTTCVSD	VTAVILFFFTFFITTMVMLAALA	HHLFYWDVWF
607	Q4V9L6	MVSAAAPSLLILLLL...PPESPCACSSVHPSV	2	95	117	DGIVDFFRQY	VMLIAVVGSLAFLLMFIVCAAVI	TRQKQKASAY
608	Q8N3G9	MAQAVWSRLGRILWL...GLLPPLYKSVKTYTV	2	340	362	IQVWPSRIQP	AVFAFPCATLITVMLAFIMYMTL	RNATQQKDMV
609	Q6P9G4	MQAPRAALVFALVIA...KEEKESNHNPSDSES	2	76	98	NFAPDENQLE	FILMVLIPLILLVLLLLSVVFLA	TYYKRKRTKQ
610	Q8WZ59	MLGCGIPALGLLLLL...GTEEGEETEGEEEED	2	82	104	PDENVRRKHM	WALVWTCSGLLLLSCSICLFWWA	KRRDVLHMPG
611	Q6UWW9	MSRSRLFSVTSAIST...PLGSPPPYEEIVKTT	2	49	71	CVNYNDQHPN	GWYIWILLLLVLVAALLCGAVVL	CLQCWLRRPR
612	A6NLX4	MAPGPWPVSCLRGGP...ASSEEPPPPPPLPPE	2	44	66	CECSLGLSRE	ALIALLVVLAGISASCFCALVIV	AIGVLRAKGE
613	A2RRL7	MQRLPAATRATLILS...KLMKLTPDEPKDLQA	2	70	89	ARCCRTGVDE	YGWIAAAVGWSLWFLTLILL	CVDKLMKLTP
614	Q5T292	MNLGVSMLRILFLLD...RNHNFSKRDAQVIEL	2	37	59	TPGAEIDFKY	ALIGTAVGVAISAGFLALKICMI	RRHLFDDDSS
615	Q4KMG9	MGVRVHVVAASALLY...PPTEKESTRIVDSWN	2	42	64	EHCLTTDWVH	LWYIWLLVVIGALLLLCGLTSLC	FRCCCLSRQQ
616	Q9D2R4	MQIQTILLCFSFSFS...QMKHLKDFFIAKKLV	2	183	202	RITSEDTNRN	VLWWAFAQILIFISVGIFQM	KHLKDFFIAK
617	P0DPE3	MAARTLASALVLTLW...KMGAQSWGSGALDGL	2	220	242	RSPMGWAGPL	ALGLLTGFVGALGTGALVVLLTL	WITGGDGDRA
618	Q13445	MMAAGAALALALWLL...CTLKRFFQDKRPVPT	2	193	215	RNLQEGNLER	VNFWSAVNVAVLLLVAVLQVCTL	KRFFQDKRPV
619	Q15363	MVTLAELLVLLAALL...QIYYLKRFFEVRRVV	2	169	191	RAINDNTNSR	VVLWSFFEALVLVAMTLGQIYYL	KRFFEVRRVV
620	Q9Y3Q3	MGSTVPRSASVLLLL...SFFTEKRPISRAVHS	2	179	201	RARAEDLNSR	VSYWSVGETIALFVVSFSQVLLL	KSFFTEKRPI
621	Q8WW62	MSPLLFGAGLVVLNL...LFNVPTTTDTKKPRC	2	201	223	FFLIQSNYNY	VNWWSTAQSLVIILSGILQLYFL	KRLFNVPTTT
622	P49755	MSGLSGPPARRGPFP...VFYLRRFFKAKKLIE	2	186	208	RDTNESTNTR	VLYFSIFSMFCLIGLATWQVFYL	RRFFKAKKLI
623	Q9P0T7	MKLLSLVAVVGCLLV...QEQRKTVFDRHKMLS	2	90	112	YEERSTTTIK	VIIVIYLSVVGALLLYMAFLMLV	DPLIRKPDAY
624	O14668	MGRVFLTGEKANSIL...SASAIPMVPVVTTIK	2	84	106	RGSDWFQFYL	TFPLIFGLFIILLVIFLIWRCFL	RNKTRRQTVT
625	O14669	MRGHPSLLLLYMALT...HDAPPPPYTSLRRPH	2	110	132	GGRGRVDVAS	LAVGLTGGILLIVLAGLGAFWYL	RWRQHRGQQP
626	Q9BZD7	MAVFLEAKDAHSVLK...PKYEEIVAANPGADK	2	79	101	SVRDPSQSSD	AMYVVVPLLGVALLIVIALFIIW	RCQLQKATRH
627	Q9BZD6	MFTLLVLLSQLPTVT...KGFRVFKKSMSLPSH	2	118	140	NREKIDVMGL	LTGLIAAGVFLVIFGLLGYYLCI	TKCNRLQHPC
628	Q8NEW7	MAGWPGAGPLCVLGG...EEDEKNEAKKKKGEK	2	56	78	KETVVFWDMR	LWHVVGIFSLFVLSIIITLCCVF	NCRVPRTRKE
629	Q9D7L8	MVWKITGPLQACQLL...KLCGKKNDPNSETAL	2	217	239	FHLLVKDKVF	VMPAEPIIAACVVVVLTMAFALF	SRRKRIMKLC
630	Q96BF3	MGSPGMVLGLLVQIW...TQQPRPKGFPKVGEE	2	150	172	QNRNRIASFP	GFLFVLLGVGSMGVAAIVWGAWF	WGRRSCQQRD
631	G3X8R9	MEFLLLLSLALFSDA...ASQGPSMVSITLARI	2	151	173	KAVQKAEGSR	MSILIICILITSLGIIFIISHLS	RGRRSQRNRE
632	Q9DCF1	MELPLSQATLRHTLL...YIYRVSSVSSDEIWL	2	238	260	ATRIEVPLLG	IVVAGGLALGTLVGFSTLVACLV	CRKEKKTKGP
633	Q9BXS4	MAAPKGSLWVRTQLG...AGPLPTKVNLAHSEI	2	240	262	FLRCLSLNSG	WILTTTLVLSVMVLLWICCATVA	TAVEQYVPSE
634	Q9D5K1	MKTGAIVFILRSLLS...KALGGTDGSGGRTRL	2	221	243	KPHLPVWQRK	VTSALGIGIVAGVVGGVLVSVAV	FKALGGTDGS
635	A2RUT3	MLHVLASLPLLLLLV...TQRQIQIKGTSTQSG	2	64	86	CPGYWLGPGA	SRIYPVAAVMITTTMLMICRKIL	QGRRRSQATK
636	Q6UXU6	MSQAWVPGLAPTLLF...EEYTGDQRGIDNPAF	2	54	76	SCCQENELFP	GPVRIFVIIFLVILSVFCICGLA	KCFCRNCREP
637	B7ZWI3	MLDTWVWGTLTLTFG...EGPAGQMRGRAYATL	2	64	86	VWDPANDRFR	FLVILACIIFPILFICALVSLFC	PNCTELQHDV
638	Q3KNT9	MWRLALGGVFLAAAQ...SLLVESHHLQAKSGL	2	146	165	PGSQDLWEAK	ILLLSIFGAFLLLGVLSLLV	ESHHLQAKSG
639	Q9H3N1	MAPSGSLAVPLAVLV...IRQRSLGPSLATDKS	2	181	203	EDLGLPVWGS	YTVFALATLFSGLLLGLCMIFVA	DCLCPSKRRR
640	Q9Y320	MAVLAPLIALVYSVP...STPTTVSDGENKKDK	2	103	125	IFMFSKVANT	ILFFRLDIRMGLLYITLCIVFLM	TCKPPLYMGP
641	O35305	MAPRARRRRQLPAPL...AQTSLHTQGSGQCAE	2	212	234	RRPPKEAQAY	LPSLIVLLLFISVVVVAAIIFGV	YYRKGGKALT
642	Q9CR75	MASAWPRSLPQILVL...EETGGEGCPGVALIQ	2	79	101	AAPPAHFRLL	WPILGGALSLVLVLALVSSFLVW	RRCRRREKFT
643	Q92956	MEPPGDWGPPPWRST...VEETIPSFTGRSPNH	2	201	223	KAGAGTSSSH	WVWWFLSGSLVIVIVCSTVGLII	CVKRRKPRGD
644	Q80WM9	MEPLPGWGSAPWSQA...TEVGFAETEEETASN	2	208	230	STDTTCSSQV	VYYVVSILLPLVIVGAGIAGFLI	CTRRHLHTSS
645	Q9Y5U5	MAQHGAMGAFRALCG...ERSAEEKGRLGDLWV	2	165	187	PGSPPAEPLG	WLTVVLLAVAACVLLLTSAQLGL	HIWQLRSQCM
646	P20333	MAPVAVWAALAVGLE...KPLPLGVPDAGMKPS	2	258	280	SPPAEGSTGD	FALPVGLIVGVTALGLLIIGVVN	CVIMTQVKKK
647	Q93038	MEQRPRGCAAVAAAL...DGCVEDLRSRLQRGP	2	200	222	RCAAVCGWRQ	MFWVQVLLAGLVVPLLLGATLTY	TYRHCWPHKP
648	P83626	MTRLRLLLLLGLLLR...YCKRGENIQLSSTML	2	163	185	SGSQCFCFSK	PLGIVVIIAAFIIIIGAVIILIL	KIICYCKRGE
649	P36941	MLLPWATSAPGLAWG...TPSNRGPRNQFITHD	2	226	248	PLPPEMSGTM	LMLAVLLPLAFFLLLATVFSCIW	KSHPSLCRKL
650	P25942	MVRLPLQCVLWGCLL...QEDGKESRISVQERQ	2	193	215	DVVCGPQDRL	RALVVIPIIFGILFAILLVLVFI	KKVAKKPTNK
651	P25446	MLWIWAVLPLVLAGS...STPDTGNENEGQCLE	2	170	187	NCRKQSPRNR	LWLLTILVLLIPLVFIYR	KYRKRKCWKR
652	P28908	MRVLLAALGLLFLGA...EEGKEDPLPTAASGK	2	386	408	STGKPVLDAG	PVLFWVILVLVVVVGSSAFLLCH	RRACRKRIRQ
653	Q07011	MGNSCYNIVATLLLV...CSCRFPEEEEGGCEL	2	191	213	PGHSPQIISF	FLALTSTALLFLLFFLTLRFSVV	KRGRKKLLYI
654	Q13641	MPGGCSRGPAAGDGR...NADPRLTNLSSNSDV	2	354	376	CDPILPPSLQ	TSYVFLGIVLALIGAIFLLVLYL	NRKGIKKWMH
655	P40238	MPSWALFMVTSCLLL...IANHSYLPLSYWQQP	2	491	513	TRVETATETA	WISLVTALHLVLGLSAVLGLLLL	RWQFPAHYRR
656	Q9BX59	MGTQEGWCLLLCLAL...SHLHEDRTARVSQPS	2	407	426	TQVVPPERRT	ALGVIFASSLFLLALMFLGL	QRRQAPTGLG
657	O15533	MKSLSLLLAVALGLA...AVYLSTCKDSKKKAE	2	414	436	GLSGPSLEDS	VGLFLSAFLLLGLFKALGWAAVY	LSTCKDSKKK
658	O00220	MAPPPARVHLGAFLA...FIYLEDGTGSAVSLE	2	240	262	VHKESGNGHN	IWVILVVTLVVPLLLVAVLIVCC	CIGSGCGGDP
659	O14763	MEQRGQNAPAASGAR...GKFMYLEGNADSAMS	2	209	231	TSSPGTPASP	CSLSGIIIGVTVAAVVLIVAVFV	CKSLLWKKVL
660	Q9UBN6	MGLWGQSVPTASSAR...LFYEEDEAGSATSCL	2	210	232	TTILGMLASP	YHYLIIIVVLVIILAVVVVGFSC	RKKFISYLKG
661	Q9JKE1	MSPLLLWLGLMLCVS...QPSKTSKVQGVSEKQ	2	138	160	LAWCQGKPVM	VIVLTCGFILNKGLVFSVLFVFL	CKAGPKVLQP
662	Q8K558	MDCYLLLLLLLLGLA...EPVQDPPNSQTPPSK	2	174	196	PHEFRRRENS	IPLIWGAVLLLALVVVAVVIFAV	MARKKGNRLV
663	Q5T2D2	MAPAFLLLLLLWPQG...DPPGRPEPYVEVYLI	2	267	289	SMPSIRHQDV	YSTVLGVVLTLLVLMLIMVYGFW	KKRHMASYSM
664	Q3LRV9	MAWRYSQLLLVPVQL...TVSHISGYEKKANWY	2	200	222	PGWTSPGLLV	SVQYGLLLLKALMLSVFCVLLCW	RSGQGREYMA
665	Q5BVD1	MDLAQPSQPVDELEL...CESLGLDPTSLLLYE	2	66	88	CNKNVVGRCK	LWMIITSIFLGVITVIIIGLCLA	AVTYVDEDEN
666	Q9P2J2	MVWCLGLAVLSLVIS...AYRQPVPHPEQATLL	2	738	760	PGLLPQPVLA	GVVGGVCFLGVAVLVSILAGCLL	NRRRAARRRR
667	Q9UPX0	MIWYVATFIASVIGT...PAPATSPPERALSKL	2	727	749	DGLARPVLAG	IVATICFLAAAILFSTLAACFVN	KQRKRKLKRK
668	Q96J42	MVPAAGRRPPRVMRL...SIRWLIPGQEQEHVE	2	324	342	LPSTLIKSVD	WLLVFSLFFLISFIMYATI	RTESIRWLIP
669	P0DTE4	MLNNLLLFSLQISLI...SCQKFGKIGKKKKRE	2	491	513	LTWFQYHSLD	VIGFLLVCVTTAIFLVIQCCLFS	CQKFGKIGKK
670	Q8IZJ1	MGARSGARGALLLAL...GKSEMLVAVATDGDC	2	376	398	HLLEASGDAA	LYAGLVVAIFVVVAILMAVGVVV	YRRNCRDFDT
671	Q80YF6	MVRTRWQPPLRALLL...VGCEPGLDPLPSLSP	2	196	218	IDTWPGRRSG	CMIVITSILSALAGLLLLAFLAA	STTRFSSLWW
672	B0FP48	MDNSWRLGPAIGLSA...YTTHLAFSTPAEGAS	2	203	225	AVPGPQSPGT	VVIIAILSILLAVLLTVLLAVLI	YTCFNSCRST
673	Q5DID0	MLRTSGLALLALVSA...FKIQSNNFSYQVFYE	2	1271	1293	PPHAEAGLGA	GYVVLIVVAIFVLVAGTATLLIV	RYQRMNGRYN
674	O75445	MNCPVLSLGSGFLFQ...SSVTKERTTFTDTHL	2	5041	5063	RSKSTEFYSE	LWFIVLMAMLGLILLAIFLSLIL	QRKIHKEPYI
675	P29533	MPVKMVAVLGASTVL...MKGSYSLVEAQKSKV	2	699	721	EHNKDYFSPE	LLALYCASSLVIPAIGMIVYFAR	KANMKGSYSL
676	Q9H7M9	MGVPTALEAGSWRWG...PSLDPVPDSPNFEVI	2	194	216	SSQDSENITA	AALATGACIVGILCLPLILLLVY	KQRQAASNRR
677	Q96AW1	MRRQPAKVAALLLGL...CNTPPPPYEQVVKAK	2	59	81	RCCVRALSIQ	RLWYFWFLLMMGVLFCCGAGFFI	RRRMYPPPLI
678	Q8N0Z9	MAAGGSAPEPRVLVC...SEEQSDIVQEEDRPV	2	412	434	WLSVKEPLNI	GGIVGTIVSLLLLGLAIISGLLL	HYSPVFCWKV
679	Q86XK7	MVFAFWKVFLILSCL...VVEPLSEDEKGVVKA	2	234	256	IDLTSSHPEV	GIIVGALIGSLVGAAIIISVVCF	ARNKAKAKAK
680	Q96IQ7	MAELPGPFLCGALLG...ASTVTTTKSKLPMVV	2	242	264	LSVTEPSQGR	VAGALIGVLLGVLLLSVAAFCLV	RFQKERGKKP
681	Q9Z109	MAWPLVGAFLCGHLL...ASTMTTTKSKLSMVV	2	243	265	LSVTDSSEGR	VAGTLIGVLLGVLLLSVAAFCLI	RFQKERKKEP
682	Q9Y279	MGILLGLLLLGHLTV...PLDYEFLATEGKSVC	2	284	306	TSAGPGKSLP	VFAIILIISLCCMVVFTMAYIML	CRKTSQQEHV
683	P0DPA2	MRVGGAFHLLLVCLS...DCAEGPVQCKNGLLV	2	265	287	KVSDSRRIGV	IIGIVLGSLLALGCLAVGIWGLV	CCCCGGSGAG
684	Q8IW00	MRLLALAAAALLARA...TSTVYAQILFEENKL	2	179	201	ETWAFFEDLY	VYAVLVCCVGILSILLFMLVIVW	QSVFNKRKSR
685	A8MXK1	MRPLPSGRRKTRGIS...KESTTEEIELEDVEC	2	148	170	VSEILYEDLH	FVAVILAFLAAVAAVLISLMWVC	NKCAYKFQRK
686	P55808	MESWWGLPCLAFLCF...NNRRNCFRTHEPENV	2	143	165	GNPEGNMVAK	IVSPIVSVVVVTLLGAAASYFKL	NNRRNCFRTH
687	Q9Y493	MVPPVWTLLLLVGAA...LARLVDTDTVLDCAC	2	2756	2778	PRDAPPPRKP	ASNLVGVLLGLLVPVVVVLLAVT	RECIYRTRRK
688	Q9ULT6	MRPRSGGRPGATGRR...AGPRSHSADSSSPGA	2	216	238	QHRPPRQPTE	YFDMGIFLAFFVVVSLVCLILLV	KIKLKQRRSQ
689	Q8WWF5	MPLCRPEHLMPRASR...EYTTVSSAPPEAPGQ	2	255	277	DLGCHPVLTV	SWVLGCTLALVVSAFFVLNHLWL	WAQACCSHRR
690	P60852	MAGGSATTWGYPVAL...LSQTWAQKLWESNRQ	2	602	624	DSNGNSSLRP	LLWAVLLLPAVALVLGFGVFVGL	SQTWAQKLWE
691	P20239	MARWQRKASVSSPCG...FICYLYKKRTIRFNH	2	684	703	IIAKDIASKT	LGAVAALVGSAVILGFICYL	YKKRTIRFNH
692	P21754	MELSYRLFICLLLWG...TRRCRTASHPVSASE	2	387	409	EQWALPSDTS	VVLLGVGLAVVVSLTLTAVILVL	TRRCRTASHP
693	Q12836	MWLLRCVLLCVSLSL...LAVKKQKSCPDQMCQ	2	506	528	EKLRVPVDSK	VLWVAGLSGTLILGALLVSYLAV	KKQKSCPDQM
694	Q8TCW7	MEQIWLLLLLTIRVL...PTSLVLNGIRNPVFD	2	374	396	PFQLNAITSA	LISGMVILGVTSFSLLLCSLALL	HRKGPTSLVL

And create their feature matrix using the SequenceFeatuer class:

sf = aa.SequenceFeature()
df_parts = sf.get_df_parts(df_seq=df_seq)
X = sf.feature_matrix(features=df_feat["feature"], df_parts=df_parts)

Using list comprehension, labels for all three Distance-based identification approaches can be retrieved using the dPULearn().fit() method with different metric parameters:

dpul = aa.dPULearn()
# List with valid distance measures
list_metrics = ["manhattan", "euclidean", "cosine"]
list_labels = [dpul.fit(X=X, labels=labels, metric=metric, n_unl_to_neg=n_pos).labels_ for metric in  list_metrics]

For the PCA-based identification, use the n_components parameter:

# List with percentage of total variance to be explaiend [0-1]
list_pca_var = [0.6, 0.7, 0.8, 0.9, 0.95]
list_labels.extend([dpul.fit(X=X, labels=labels, n_components=i, n_unl_to_neg=n_pos).labels_ for i in list_pca_var])

Now, the dPULearn().eval() and dPULearnPlot().eval() methods can be used:

names = list_metrics + [f"pca (var {int(x*100)}%)" for x in list_pca_var]
df_eval = dpul.eval(X=X, list_labels=list_labels, names_datasets=names)
dpul_plot = aa.dPULearnPlot()
dpul_plot.eval(df_eval=df_eval)
plt.tight_layout()
plt.show()

Extend the analysis by using a dataset of ground-truth negatives:

_df_seq = aa.load_dataset(name="DOM_GSEC")
# First 14 entries are ground-truth non-substrates
df_neg = _df_seq[_df_seq["label"] == 0].head(14)
df_parts_neg = sf.get_df_parts(df_seq=df_neg)
X_neg = sf.feature_matrix(features=df_feat["feature"], df_parts=df_parts_neg)
# Perform evaluation and visualization
df_eval = dpul.eval(X=X, list_labels=list_labels, names_datasets=names, X_neg=X_neg)
dpul_plot.eval(df_eval=df_eval)
plt.show()

You can effectively utilize the Kullback-Leibler Divergence (KLD) as a complementary measure alongside the adjusted area under the curve (AUC) to evaluate the dissimilarity between sets of identified negatives and reference datasets. These reference datasets include positive samples (‘Pos’), unlabeled samples (‘Unl’), and, when available, ground-truth negative samples (‘Neg’).

df_eval = dpul.eval(X=X, list_labels=list_labels, names_datasets=names, X_neg=X_neg, comp_kld=True)
dpul_plot.eval(df_eval=df_eval)
plt.show()

The legend can be turned-of by legend=False or shifted along the y-axis using legend_y, handy if the figsize is changed:

dpul_plot.eval(df_eval=df_eval, figsize=(8, 5), legend_y=-0.1)
plt.show()

You can customize the list of used colors:

dpul_plot.eval(df_eval=df_eval, colors=["r", "g", "b", "y"])
plt.show()

Customize the x-limits of each subplot using the dict_xlims parameter:

dict_xlims = {0: (0, 0.2), 3: (0, 0.5)} # Adjust first and fourth subplot
dpul_plot.eval(df_eval=df_eval, dict_xlims=dict_xlims)
plt.show()